Surgical site infections after kidney transplantation are independently associated with graft loss.
Details
Request a copy Under indefinite embargo.UNIL restricted access
State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_5E28895E3E42
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Surgical site infections after kidney transplantation are independently associated with graft loss.
Journal
American journal of transplantation
Working group(s)
members of the Swiss Transplant Cohort Study (STCS)
Contributor(s)
Amico P., Aubert J.D., Banz V., Beckmann S., Beldi G., Berger C., Berishvili E., Berzigotti A., Binet I., Bochud P.Y., Branca S., Bucher H., Catana E., Cairoli A., Chalandon Y., De Geest S., De Rougemont O., De Seigneux S., Dickenmann M., Dreifuss J.L., Duchosal M., Fehr T., Ferrari-Lacraz S., Garzoni C., Golshayan D., Goossens N., Haidar F., Halter J., Heim D., Hess C., Hillinger S., Hirsch H.H., Hirt P., Hoessly L., Hofbauer G., Huynh-Do U., Immer F., Koller M., Laesser B., Lamoth F., Lehmann R., Leichtle A., Manuel O., Marti H.P., Martinelli M., McLin V., Mellac K., Merçay A., Mettler K., Mueller N.J., Müller-Arndt U., Müllhaupt B., Nägeli M., Oldani G., Pascual M., Passweg J., Pazeller R., Posfay-Barbe K., Rick J., Rosselet A., Rossi S., Rothlin S., Ruschitzka F., Schachtner T., Schaub S., Scherrer A., Schnyder A., Schuurmans M., Schwab S., Sengstag T., Simonetta F., Stampf S., Steiger J., Stirnimann G., Stürzinger U., Van Delden C., Venetz J.P., Villard J., Vionnet J., Wick M., Wilhelm M., Yerly P.
ISSN
1600-6143 (Electronic)
ISSN-L
1600-6135
Publication state
Published
Issued date
05/2024
Peer-reviewed
Oui
Volume
24
Number
5
Pages
795-802
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Multicenter Study
Publication Status: ppublish
Publication Status: ppublish
Abstract
Surgical site infections (SSIs) are common health care-associated infections. SSIs after kidney transplantation (K-Tx) can endanger patient and allograft survival. Multicenter studies on this early posttransplant complication are scarce. We analyzed consecutive adult K-Tx recipients enrolled in the Swiss Transplant Cohort Study who received a K-Tx between May 2008 and September 2020. All data were prospectively collected with the exception of the categorization of SSI which was performed retrospectively according to the Centers for Disease Control and Prevention criteria. A total of 58 out of 3059 (1.9%) K-Tx recipients were affected by SSIs. Deep incisional (15, 25.9%) and organ/space infections (34, 58.6%) predominated. In the majority of SSIs (52, 89.6%), bacteria were detected, most frequently Escherichia coli (15, 28.9%), Enterococcus spp. (14, 26.9%), and coagulase-negative staphylococci (13, 25.0%). A BMI ≥25 kg/m <sup>2</sup> (multivariable OR 2.16, 95% CI 1.07-4.34, P = .023) and delayed graft function (multivariable OR 2.88, 95% CI 1.56-5.34, P = .001) were independent risk factors for SSI. In Cox proportional hazard models, SSI was independently associated with graft loss (multivariable HR 3.75, 95% CI 1.35-10.38, P = .011). In conclusion, SSI was a rare complication after K-Tx. BMI ≥25 kg/m <sup>2</sup> and delayed graft function were independent risk factors. SSIs were independently associated with graft loss.
Keywords
Humans, Kidney Transplantation/adverse effects, Surgical Wound Infection/etiology, Surgical Wound Infection/microbiology, Surgical Wound Infection/epidemiology, Male, Female, Middle Aged, Risk Factors, Graft Survival, Graft Rejection/etiology, Retrospective Studies, Follow-Up Studies, Kidney Failure, Chronic/surgery, Prognosis, Adult, Glomerular Filtration Rate, Prospective Studies, Delayed Graft Function/etiology, Aged, Switzerland/epidemiology, Kidney Function Tests, graft loss, health care-associated infection, kidney transplantation, surgical site infection
Pubmed
Web of science
Create date
07/12/2023 16:04
Last modification date
10/08/2024 6:30
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