PPARs in diseases: control mechanisms of inflammation.

Details

Serval ID
serval:BIB_5E19ECA41F0F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
PPARs in diseases: control mechanisms of inflammation.
Journal
Current Medicinal Chemistry
Author(s)
Kostadinova R., Wahli W., Michalik L.
ISSN
0929-8673[print], 0929-8673[linking]
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
12
Number
25
Pages
2995-3009
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The three isotypes of peroxisome proliferator-activated receptors (PPARs), PPARalpha, beta/delta and gamma, are ligand-inducible transcription factors that belong to the nuclear hormone receptor family. PPARs are implicated in the control of inflammatory responses and in energy homeostasis and thus, can be defined as metabolic and anti-inflammatory transcription factors. They exert their anti-inflammatory effects by inhibiting the induction of pro-inflammatory cytokines, adhesion molecules and extracellular matrix proteins or by stimulating the production of anti-inflammatory molecules. Furthermore, PPARs modulate the proliferation, differentiation and survival of immune cells including macrophages, B cells and T cells. This review discusses the molecular mechanisms by which PPARs and their ligands modulate the inflammatory response. In addition, it presents recent developments implicating PPAR specific ligands in potential treatments of inflammation-related diseases, such as atherosclerosis, inflammatory bowel diseases, Parkinson's and Alzheimer's diseases.
Keywords
Animals, Anti-Inflammatory Agents/pharmacology, Anti-Inflammatory Agents/therapeutic use, Humans, Inflammation/drug therapy, Inflammation/immunology, Ligands, Models, Immunological, Peroxisome Proliferator-Activated Receptors/drug effects, Peroxisome Proliferator-Activated Receptors/immunology, Structure-Activity Relationship
Pubmed
Web of science
Create date
24/01/2008 15:44
Last modification date
20/08/2019 14:16
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