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BAFF production by antigen-presenting cells provides T cell co-stimulation.
The B cell-activating factor from the tumor necrosis factor family (BAFF) is an important regulator of B cell immunity. Recently, we demonstrated that recombinant BAFF also provides a co-stimulatory signal to T cells. Here, we studied expression of BAFF in peripheral blood leukocytes and correlated this expression with BAFF T cell co-stimulatory function. BAFF is produced by antigen-presenting cells (APC). Blood dendritic cells (DC) as well as DC differentiated in vitro from monocytes or CD34+ stem cells express BAFF mRNA. Exposure to bacterial products further up-regulates BAFF production in these cells. A low level of BAFF transcription, up-regulated upon TCR stimulation, was also detected in T cells. Functionally, blockade of endogenous BAFF produced by APC and, to a lesser extent, by T cells inhibits T cell activation. Altogether, this indicates that BAFF may regulate T cell immunity during APC-T cell interactions and as an autocrine factor once T cells have detached from the APC.
B-Cell Activating Factor, Cell Communication/immunology, Dendritic Cells/immunology, Gene Expression, Genes, MHC Class II/genetics, Humans, Lymphocyte Activation, Membrane Proteins/biosynthesis, Membrane Proteins/genetics, RNA, Messenger/metabolism, Receptor-CD3 Complex, Antigen, T-Cell/genetics, Receptor-CD3 Complex, Antigen, T-Cell/immunology, Recombinant Proteins/genetics, Recombinant Proteins/immunology, T-Lymphocytes/immunology, Tumor Necrosis Factor-alpha/biosynthesis, Tumor Necrosis Factor-alpha/genetics, Up-Regulation/genetics
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