HAMAP in 2015: updates to the protein family classification and annotation system.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_5DB1309B2F88
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
HAMAP in 2015: updates to the protein family classification and annotation system.
Périodique
Nucleic Acids Research
Auteur(s)
Pedruzzi I., Rivoire C., Auchincloss A.H., Coudert E., Keller G., de Castro E., Baratin D., Cuche B.A., Bougueleret L., Poux S., Redaschi N., Xenarios I., Bridge A.
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Statut éditorial
Publié
Date de publication
2015
Volume
43
Numéro
Database issue
Pages
D1064-D1070
Langue
anglais
Résumé
HAMAP (High-quality Automated and Manual Annotation of Proteins-available at http://hamap.expasy.org/) is a system for the automatic classification and annotation of protein sequences. HAMAP provides annotation of the same quality and detail as UniProtKB/Swiss-Prot, using manually curated profiles for protein sequence family classification and expert curated rules for functional annotation of family members. HAMAP data and tools are made available through our website and as part of the UniRule pipeline of UniProt, providing annotation for millions of unreviewed sequences of UniProtKB/TrEMBL. Here we report on the growth of HAMAP and updates to the HAMAP system since our last report in the NAR Database Issue of 2013. We continue to augment HAMAP with new family profiles and annotation rules as new protein families are characterized and annotated in UniProtKB/Swiss-Prot; the latest version of HAMAP (as of 3 September 2014) contains 1983 family classification profiles and 1998 annotation rules (up from 1780 and 1720). We demonstrate how the complex logic of HAMAP rules allows for precise annotation of individual functional variants within large homologous protein families. We also describe improvements to our web-based tool HAMAP-Scan which simplify the classification and annotation of sequences, and the incorporation of an improved sequence-profile search algorithm.
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/02/2015 17:42
Dernière modification de la notice
20/08/2019 14:15
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