Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
Details
Serval ID
serval:BIB_5D7CC64F7F6B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
Journal
Neurology
ISSN
0028-3878
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
60
Number
9
Pages
1495-1500
Language
english
Notes
AN - Peer Reviewed Journal: 2003-99079-008 MA - Giannakopoulos [P.: Panteleimon.Giannakopoulos@medecine.unige.ch LG - English Empirical Study. Quantitative Study. Journal Article PT - Peer Reviewed Journal RF - Amaral, D. G., & Insausti, R. (1990). Hippocampal formation. In: Paxinos G, ed. The human nervous system. San Diego: Academic Press, 1990:711-755 Institution : Department of Psychiatry, HUG Belle-Idee, University of Geneva School of Medicine, Geneva, Switzerland Department of Geriatrics, HUG Belle-Idee, University of Geneva School of Medicine, Geneva, Switzerland Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, NY, US Department of Psychiatry, HUG Belle-Idee, University of Geneva School of Medicine, Geneva, Switzerland Department of Psychiatry, HUG Belle-Idee, University of Geneva School of Medicine, Geneva, Switzerland Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, NY, US Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, NY, US Department of Geriatrics, HUG Belle-Idee, University of Geneva School of Medicine, Geneva, Switzerland Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, NY, US SAPHIRID:48136 --- Old url value: http://www.neurology.org/cgi/content/full/60/9/1495
Abstract
Examined the relationship between stereologic estimates of Alzheimer's disease (AD)-related pathology and severity of cognitive deficits in brain aging. Previous studies reported substantial contributions of neurofibrillary tangles (NFT), amyloid deposits, and neuronal loss to the development of dementia. Clinicopathologic study in 22 elderly cases. Cognitive status assessed prospectively using the Mini-Mental State Examination (MMSE); stereologic assessment of NFT, unaffected neurons, and total amyloid volume in the CAI field of the hippocampus, entorhinal cortex, and area 9. Statistical analysis was performed using both univariate and multivariate linear regression models. High total NFT counts but not amyloid volume were strongly associated with a lower number of unaffected neurons in all areas studied. A high proportion of variability in MMSE scores was explained by NFT and neuronal counts in the CAI field (83% and 85.4%), entorhinal cortex (87.8% and 83.7%), and area 9 (87% and 79%); amyloid volume in the entorhinal cortex, but not in the CA1 field and area 9, accounted for 58.5% of MMSE variability. Multivariate analyses showed that total NFT counts in the entorhinal cortex and area 9 as well as neuron numbers in the CAI field were the best predictors of MMSE score. (PsycINFO Database Record (c) 2004 APA, all rights reserved)
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Create date
10/03/2008 12:04
Last modification date
20/08/2019 15:15
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