Hepatitis C virus infection after liver transplantation is associated with lower levels of activated CD4(+)CD25(+)CD45RO(+)IL-7ralpha(high) T cells.

Détails

ID Serval
serval:BIB_5D74E00D85A8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Hepatitis C virus infection after liver transplantation is associated with lower levels of activated CD4(+)CD25(+)CD45RO(+)IL-7ralpha(high) T cells.
Périodique
Liver Transplantation : Official Publication of the American Association For the Study of Liver Diseases and the International Liver Transplantation Society
Auteur(s)
Ciuffreda D., Codarri L., Buhler L., Vallotton L., Giostra E., Mentha G., Morel P., Pantaleo G., Pascual M.
ISSN
1527-6473[electronic], 1527-6465[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
16
Numéro
1
Pages
49-55
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The expression of interleukin 7 receptor alpha(high) (IL-7Ralpha(high)) discriminates between activated CD25(+)CD45RO(+)CD4(+) T cells [IL-7Ralpha(high) and forkhead box P3-negative (FoxP3(-))] and regulatory T cells (IL-7Ralpha(low) and FoxP3(+)). The IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cell population has been shown to be expanded in the blood and tissues of patients after kidney transplantation and to contain alloreactive T cells (activated T cells). In the present study, we analyzed the distribution of IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cells in the blood of 53 patients after liver transplantation. The IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cell population was significantly expanded (P < 0.0001) in stable transplant recipients versus healthy donors. However, the magnitude of the expansion was significantly higher (P < 0.0001) in liver transplant recipients with no hepatitis C virus (HCV) infection in comparison with those with a preexisting HCV infection. Interestingly, effective suppression of HCV viremia after antiviral therapy was associated with an increase in the IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cell population to levels comparable to those of liver transplant recipients not infected with HCV. The present results indicate that (1) the IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cell population is expanded after liver transplantation, (2) it is a valuable immunological marker for monitoring activated and potential alloreactive CD4 T cells in liver transplantation, and (3) a preexisting HCV infection negatively influences the expansion of this population in liver transplant recipients.
Mots-clé
Adult, Aged, Antiviral Agents/therapeutic use, Case-Control Studies, Down-Regulation, Female, Hepatitis C, Chronic/drug therapy, Hepatitis C, Chronic/immunology, Humans, Interleukin-7 Receptor alpha Subunit/metabolism, Liver Transplantation, Male, Middle Aged, Postoperative Complications/immunology, T-Lymphocytes, Regulatory/metabolism, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/01/2010 15:21
Dernière modification de la notice
20/08/2019 14:15
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