Brain tissue properties differentiate between motor and limbic basal ganglia circuits.

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Serval ID
serval:BIB_5D584C5278D3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Brain tissue properties differentiate between motor and limbic basal ganglia circuits.
Journal
Human Brain Mapping
Author(s)
Accolla E.A., Dukart J., Helms G., Weiskopf N., Kherif F., Lutti A., Chowdhury R., Hetzer S., Haynes J.D., Kühn A.A., Draganski B.
ISSN
1097-0193 (Electronic)
ISSN-L
1065-9471
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
35
Number
10
Pages
5083-92
Language
english
Notes
Publication types: JOURNAL ARTICLE
Abstract
Despite advances in understanding basic organizational principles of the human basal ganglia, accurate in vivo assessment of their anatomical properties is essential to improve early diagnosis in disorders with corticosubcortical pathology and optimize target planning in deep brain stimulation. Main goal of this study was the detailed topological characterization of limbic, associative, and motor subdivisions of the subthalamic nucleus (STN) in relation to corresponding corticosubcortical circuits. To this aim, we used magnetic resonance imaging and investigated independently anatomical connectivity via white matter tracts next to brain tissue properties. On the basis of probabilistic diffusion tractography we identified STN subregions with predominantly motor, associative, and limbic connectivity. We then computed for each of the nonoverlapping STN subregions the covariance between local brain tissue properties and the rest of the brain using high-resolution maps of magnetization transfer (MT) saturation and longitudinal (R1) and transverse relaxation rate (R2*). The demonstrated spatial distribution pattern of covariance between brain tissue properties linked to myelin (R1 and MT) and iron (R2*) content clearly segregates between motor and limbic basal ganglia circuits. We interpret the demonstrated covariance pattern as evidence for shared tissue properties within a functional circuit, which is closely linked to its function. Our findings open new possibilities for investigation of changes in the established covariance pattern aiming at accurate diagnosis of basal ganglia disorders and prediction of treatment outcome.
Pubmed
Web of science
Open Access
Yes
Create date
18/05/2014 15:52
Last modification date
20/08/2019 14:15
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