Connexin43-dependent mechanism modulates renin secretion and hypertension

Détails

ID Serval
serval:BIB_5D17A99383AC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Connexin43-dependent mechanism modulates renin secretion and hypertension
Périodique
Journal of Clinical Investigation
Auteur(s)
Haefliger  J. A., Krattinger  N., Martin  D., Pedrazzini  T., Capponi  A., Doring  B., Plum  A., Charollais  A., Willecke  K., Meda  P.
ISSN
0021-9738 (Print)
Statut éditorial
Publié
Date de publication
02/2006
Volume
116
Numéro
2
Pages
405-13
Notes
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
To investigate the function of Cx43 during hypertension, we studied the mouse line Cx43KI32 (KI32), in which the coding region of Cx32 replaces that of Cx43. Within the kidneys of homozygous KI32 mice, Cx32 was expressed in cortical and medullary tubules, as well as in some extra- and intraglomerular vessels, i.e., at sites where Cx32 and Cx43 are found in WT mice. Under such conditions, renin expression was much reduced compared with that observed in the kidneys of WT and heterozygous KI32 littermates. After exposure to a high-salt diet, all mice retained a normal blood pressure. However, whereas the levels of renin were significantly reduced in the kidneys of WT and heterozygous KI32 mice, reaching levels comparable to those observed in homozygous littermates, they were not further affected in the latter animals. Four weeks after the clipping of a renal artery (the 2-kidney, 1-clip [2K1C] model), 2K1C WT and heterozygous mice showed an increase in blood pressure and in the circulating levels of renin, whereas 2K1C homozygous littermates remained normotensive and showed unchanged plasma renin activity. Hypertensive, but not normotensive, mice also developed cardiac hypertrophy. The data indicate that replacement of Cx43 by Cx32 is associated with decreased expression and secretion of renin, thus preventing the renin-dependent hypertension that is normally induced in the 2K1C model.
Mots-clé
Animals Blood Pressure/physiology Connexin 43/genetics/*metabolism Connexins/genetics/metabolism Hypertension/*metabolism Kidney Tubules/cytology/metabolism Mice Mice, Inbred Strains Mice, Transgenic RNA, Messenger/metabolism Renal Artery Obstruction Renin/genetics/*secretion Sodium, Dietary
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 14:48
Dernière modification de la notice
20/08/2019 15:15
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