Molecular insights for optimizing T cell receptor specificity against cancer.

Détails

Ressource 1Télécharger: BIB_5D02888E4E45.P001.pdf (1032.36 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_5D02888E4E45
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Molecular insights for optimizing T cell receptor specificity against cancer.
Périodique
Frontiers In Immunology
Auteur(s)
Hebeisen M., Oberle S.G., Presotto D., Speiser D.E., Zehn D., Rufer N.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Statut éditorial
Publié
Date de publication
2013
Volume
4
Pages
154
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Cytotoxic CD8 T cells mediate immunity to pathogens and they are able to eliminate malignant cells. Immunity to viruses and bacteria primarily involves CD8 T cells bearing high affinity T cell receptors (TCRs), which are specific to pathogen-derived (non-self) antigens. Given the thorough elimination of high affinity self/tumor-antigen reactive T cells by central and peripheral tolerance mechanisms, anti-cancer immunity mostly depends on TCRs with intermediate-to-low affinity for self-antigens. Because of this, a promising novel therapeutic approach to increase the efficacy of tumor-reactive T cells is to engineer their TCRs, with the aim to enhance their binding kinetics to pMHC complexes, or to directly manipulate the TCR-signaling cascades. Such manipulations require a detailed knowledge on how pMHC-TCR and co-receptors binding kinetics impact the T cell response. In this review, we present the current knowledge in this field. We discuss future challenges in identifying and targeting the molecular mechanisms to enhance the function of natural or TCR-affinity optimized T cells, and we provide perspectives for the development of protective anti-tumor T cell responses.
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/08/2013 17:02
Dernière modification de la notice
20/08/2019 15:15
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