Visual attention in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study VIA 7.

Details

Serval ID
serval:BIB_5CC9D09602CE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Visual attention in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study VIA 7.
Journal
Journal of affective disorders
Author(s)
Hemager N., Vangkilde S., Thorup A., Christiani C., Ellersgaard D., Spang K.S., Burton B.K., Greve A.N., Gantriis D.L., Mors O., Jepsen JRM, Nordentoft M., Plessen K.J.
ISSN
1573-2517 (Electronic)
ISSN-L
0165-0327
Publication state
Published
Issued date
01/11/2019
Peer-reviewed
Oui
Volume
258
Pages
56-65
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Attention deficits are found in children at familial high risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) using assessment methods relying on motor-based response latency. This study compares visual attention functions in children at FHR-SZ or FHR-BP with controls using an unspeeded task unconfounded by motor components.
Visual attention was assessed in 133 7-year-old children at FHR-SZ (N = 56) or FHR-BP (N = 32), and controls (N = 45) using the unspeeded paradigm, TVA-based whole report. We compared four parameters of visual attention: visual processing speed, visual short-term memory, threshold for visual perception, and error rate. Further, we investigated their potential relationships with severity of psychopathology, adequacy of the home environment, and neurocognitive measures.
Children at FHR-SZ displayed significant deficits in perceptual processing speed of visual attention compared with controls (p < .001; d = 0.75) as did children at FHR-BP (p < .05; d = 0.54). Visual processing speed was significantly associated with spatial working memory (β = -0.23; t(68) = -3.34, p = .01) and psychomotor processing speed (β = 0.14, t(67) = 2.11, p < .05).
Larger group sizes would have permitted inclusion of more predictors in the search for neurocognitive and other factors associated with the parameters of TVA-based whole report.
Young children at FHR-SZ and FHR-BP display significant deficits in processing speed of visual attention, which may reflect the effect of shared vulnerability risk genes. Early identification of children at FHR-SZ and FHR-BP with perceptual processing speed impairments may represent a low-cost basis for low-risk interventions.
Keywords
Adult, Attention/physiology, Bipolar Disorder/psychology, Child, Child, Preschool, Cognition, Denmark, Female, Humans, Male, Memory, Short-Term/physiology, Neuropsychological Tests, Reaction Time/physiology, Risk, Schizophrenia, Schizophrenic Psychology, Visual Perception, Bipolar disorder, Familial high risk, Visual attention
Pubmed
Web of science
Create date
15/08/2019 8:47
Last modification date
25/07/2020 5:19
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