Meta-analyses identify DNA methylation associated with kidney function and damage.

Schlosser, P.; Tin, A.; Matias-Garcia, P.R.; Thio, CHL; Joehanes, R.; Liu, H.; Weihs, A.; Yu, Z.; Hoppmann, A.; Grundner-Culemann, F.; Min, J.L.; Adeyemo, A.A.; Agyemang, C.; Ärnlöv, J.; Aziz, N.A.; Baccarelli, A.; Bochud, M.; Brenner, H.; Breteler, MMB; Carmeli, C.; Chaker, L.; Chambers, J.C.; Cole, S.A.; Coresh, J.; Corre, T.; Correa, A.; Cox, S.R.; de Klein, N.; Delgado, G.E.; Domingo-Relloso, A.; Eckardt, K.U.; Ekici, A.B.; Endlich, K.; Evans, K.L.; Floyd, J.S.; Fornage, M.; Franke, L.; Fraszczyk, E.; Gao, X.; Gào, X.; Ghanbari, M.; Ghasemi, S.; Gieger, C.; Greenland, P.; Grove, M.L.; Harris, S.E.; Hemani, G.; Henneman, P.; Herder, C.; Horvath, S.; Hou, L.; Hurme, M.A.; Hwang, S.J.; Jarvelin, M.R.; Kardia, SLR; Kasela, S.; Kleber, M.E.; Koenig, W.; Kooner, J.S.; Kramer, H.; Kronenberg, F.; Kühnel, B.; Lehtimäki, T.; Lind, L.; Liu, D.; Liu, Y.; Lloyd-Jones, D.M.; Lohman, K.; Lorkowski, S.; Lu, A.T.; Marioni, R.E.; März, W.; McCartney, D.L.; Meeks, KAC; Milani, L.; Mishra, P.P.; Nauck, M.; Navas-Acien, A.; Nowak, C.; Peters, A.; Prokisch, H.; Psaty, B.M.; Raitakari, O.T.; Ratliff, S.M.; Reiner, A.P.; Rosas, S.E.; Schöttker, B.; Schwartz, J.; Sedaghat, S.; Smith, J.A.; Sotoodehnia, N.; Stocker, H.R.; Stringhini, S.; Sundström, J.; Swenson, B.R.; Tellez-Plaza, M.; van Meurs, JBJ; van Vliet-Ostaptchouk, J.V.; Venema, A.; Verweij, N.; Walker, R.M.; Wielscher, M.; Winkelmann, J.; Wolffenbuttel, BHR; Zhao, W.; Zheng, Y.; Loh, M.; Snieder, H.; Levy, D.; Waldenberger, M.; Susztak, K.; Köttgen, A.; Teumer, A.

doi:10.1038/s41467-021-27234-3

Meta-analyses identify DNA methylation associated with kidney function and damage.

Details

Download: 34887417_BIB_5CB7B327B481.pdf (3859.21 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0

Serval ID

serval:BIB_5CB7B327B481

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Meta-analyses identify DNA methylation associated with kidney function and damage.

Journal

Nature communications

Author(s)

Schlosser P., Tin A., Matias-Garcia P.R., Thio CHL, Joehanes R., Liu H., Weihs A., Yu Z., Hoppmann A., Grundner-Culemann F., Min J.L., Adeyemo A.A., Agyemang C., Ärnlöv J., Aziz N.A., Baccarelli A., Bochud M., Brenner H., Breteler MMB, Carmeli C., Chaker L., Chambers J.C., Cole S.A., Coresh J., Corre T., Correa A., Cox S.R., de Klein N., Delgado G.E., Domingo-Relloso A., Eckardt K.U., Ekici A.B., Endlich K., Evans K.L., Floyd J.S., Fornage M., Franke L., Fraszczyk E., Gao X., Gào X., Ghanbari M., Ghasemi S., Gieger C., Greenland P., Grove M.L., Harris S.E., Hemani G., Henneman P., Herder C., Horvath S., Hou L., Hurme M.A., Hwang S.J., Jarvelin M.R., Kardia SLR, Kasela S., Kleber M.E., Koenig W., Kooner J.S., Kramer H., Kronenberg F., Kühnel B., Lehtimäki T., Lind L., Liu D., Liu Y., Lloyd-Jones D.M., Lohman K., Lorkowski S., Lu A.T., Marioni R.E., März W., McCartney D.L., Meeks KAC, Milani L., Mishra P.P., Nauck M., Navas-Acien A., Nowak C., Peters A., Prokisch H., Psaty B.M., Raitakari O.T., Ratliff S.M., Reiner A.P., Rosas S.E., Schöttker B., Schwartz J., Sedaghat S., Smith J.A., Sotoodehnia N., Stocker H.R., Stringhini S., Sundström J., Swenson B.R., Tellez-Plaza M., van Meurs JBJ, van Vliet-Ostaptchouk J.V., Venema A., Verweij N., Walker R.M., Wielscher M., Winkelmann J., Wolffenbuttel BHR, Zhao W., Zheng Y., Loh M., Snieder H., Levy D., Waldenberger M., Susztak K., Köttgen A., Teumer A.

Working group(s)

Estonian Biobank Research Team, Genetics of DNA Methylation Consortium

Contributor(s)

Milani L.

ISSN

2041-1723 (Electronic)

ISSN-L

2041-1723

Publication state

Published

Issued date

09/12/2021

Peer-reviewed

Oui

Volume

Number

Pages

7174

Language

english

Notes

Publication types: Journal Article
Publication Status: epublish

Abstract

Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = 33,605) and urinary albumin-to-creatinine ratio (n = 15,068) and detected 69 and seven CpG sites where DNA methylation was associated with the respective trait. The majority of these findings showed directionally consistent associations with the respective clinical outcomes chronic kidney disease and moderately increased albuminuria. Associations of DNA methylation with kidney function, such as CpGs at JAZF1, PELI1 and CHD2 were validated in kidney tissue. Methylation at PHRF1, LDB2, CSRNP1 and IRF5 indicated causal effects on kidney function. Enrichment analyses revealed pathways related to hemostasis and blood cell migration for estimated glomerular filtration rate, and immune cell activation and response for urinary albumin-to-creatinineratio-associated CpGs.

URN

urn:nbn:ch:serval-BIB_5CB7B327B4813

OAI-PMH

oai:serval.unil.ch:BIB_5CB7B327B481

DOI

10.1038/s41467-021-27234-3

Pubmed

34887417

Web of science

000728562700022

Open Access

Yes