Article: article from journal or magazin.
A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells
Proceedings of the National Academy of Sciences of the United States of America
PT - In Vitro PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S
CD40 is a B-cell surface molecule that has been shown to induce B-cell growth upon ligation with monoclonal antibodies. This report shows that triggering via CD40 is essential for the activation of resting B cells by helper T cells (Th). A soluble fusion protein of CD40 and human immunoglobulin, CD40-Ig, inhibited the induction of B-cell cycle entry, proliferation, and differentiation by activated Th1 and Th2. The ligand for CD40 was identified as a 39-kDa membrane protein that was selectively expressed on activated Th. A monoclonal antibody specific for the 39-kDa protein inhibited CD40-Ig binding and also inhibited the activation of B cells by Th. These data indicate that the 39-kDa membrane protein expressed on activated Th is a binding protein for CD40 and functions to transduce the signal for Th-dependent B-cell activation
Animals/Antibodies/Antibodies,Monoclonal/Antibody Formation/Antigens/Antigens,CD/Antigens,CD40/Antigens,Differentiation,B-Lymphocyte/Antigens,Surface/B-Lymphocytes/Cell Cycle/Cell Differentiation/cytology/immunology/Lymphocyte Activation/Lymphocyte Cooperation/Membrane Proteins/metabolism/Mice/Mice,Inbred DBA/physiology/Protein Binding/Proteins/Research/Signal Transduction/T-Lymphocytes,Helper-Inducer
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