Timing is everything: dendritic cell subsets in murine Leishmania infection.

Détails

ID Serval
serval:BIB_5CA89D6B9998
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Timing is everything: dendritic cell subsets in murine Leishmania infection.
Périodique
Trends in Parasitology
Auteur(s)
Ashok D., Acha-Orbea H.
ISSN
1471-5007 (Electronic)
ISSN-L
1471-4922
Statut éditorial
Publié
Date de publication
2014
Volume
30
Numéro
10
Pages
499-507
Langue
anglais
Résumé
Mouse models of Leishmania major infection have shown that a predominant CD4(+) T helper type 1 cell (Th1) response leads to protection, while T helper type 2 cell (Th2) predominance confers susceptibility. Dendritic cells (DCs) are antigen-presenting cells that orchestrate the T cell response. The immune response to L. major involves direct antigen presentation by migrating DCs or transfer of antigens to resident DCs to prime T cells. In this review, we discuss the timing and consequences of antigen presentation by DC subsets and how this affects Leishmania susceptibility. We propose a model where dermal DCs and Langerhans cells play a role early in infection, followed by inflammatory monocyte-derived DC and lymph node (LN)-resident DCs at later time points of infection to establish the resistant Th1 response.
Mots-clé
Animals, Antigen Presentation/immunology, Dendritic Cells/immunology, Leishmania/immunology, Leishmaniasis/immunology, Mice, Th1 Cells/immunology
Pubmed
Web of science
Création de la notice
20/11/2014 11:35
Dernière modification de la notice
20/08/2019 15:15
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