Local delivery of bisphosphonate from coated orthopedic implants increases implants mechanical stability in osteoporotic rats

Détails

ID Serval
serval:BIB_5C86849D3B42
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Local delivery of bisphosphonate from coated orthopedic implants increases implants mechanical stability in osteoporotic rats
Périodique
Journal of Biomedical Materials Research. Part A
Auteur(s)
Peter  B., Gauthier  O., Laib  S., Bujoli  B., Guicheux  J., Janvier  P., van Lenthe  G. H., Muller  R., Zambelli  P. Y., Bouler  J. M., Pioletti  D. P.
ISSN
1549-3296 (Print)
Statut éditorial
Publié
Date de publication
01/2006
Volume
76
Numéro
1
Pages
133-43
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Résumé
Patients with osteoporosis and joint disabilities represent a constant growing and challenging population to be treated in the musculoskeletal clinical field. Especially in the case of total hip arthroplasty, new solutions should be developed to compensate for the double negative factors, peri-implant osteolysis, and osteoporotic bone loss, affecting the quality of implant outcome. The goal of this study was then to establish a proof of concept for orthopedic implant used as Zoledronate delivery in osteoporotic rats, and in particular, to verify if this approach could increase the initial implant stability. Twenty-five female 6-month-old Wistar rats were ovariectomized 6 weeks before the implantation to induce osteoporosis. The animals were randomly separated in five groups representing the different Zoledronate concentrations in the HA coating: 0, 0.2, 2.1, 8.5, and 16 microg/implant. Histomorphometric measures and peri-implant bone volume fraction were assessed and mechanical stability tests were performed. Bone volume fraction and biomechanical results clearly illustrate the positive effect of Zoledronate coated implants in the osteoporotic rats. A remarkable result was to show the existence of a window of Zoledronate content (0.2 to 8.5 microg/implant) in which the mechanical fixation of the implant increased. We were able to establish the proof of concept for orthopedic implants used as a drug delivery system in osteoporotic rats. The local bisphosphonate delivery from a calcium phosphate coating allowed increase of the mechanical fixation of an orthopedic implant. This study shows that orthopedic implants containing bisphosphonates could be beneficial for osteoporotic patients in need of a total joint replacement.
Mots-clé
Animals Biomechanics Bone and Bones/drug effects/physiopathology/surgery *Coated Materials, Biocompatible Diphosphonates/*administration & dosage Female Humans Imidazoles/*administration & dosage Microscopy, Electron, Scanning Osteoporosis/*drug therapy/physiopathology/*surgery *Prostheses and Implants Rats Rats, Wistar Surface Properties
Pubmed
Web of science
Création de la notice
28/01/2008 12:29
Dernière modification de la notice
20/08/2019 14:15
Données d'usage