Lipid-rich variant of appendiceal well-differentiated endocrine tumor (carcinoid).

Détails

ID Serval
serval:BIB_5C6B17885582
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Lipid-rich variant of appendiceal well-differentiated endocrine tumor (carcinoid).
Périodique
American Journal of Clinical Pathology
Auteur(s)
La Rosa S., Finzi G., Puppa G., Capella C.
ISSN
1943-7722 (Electronic)
ISSN-L
0002-9173
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
133
Numéro
5
Pages
809-814
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Well-differentiated endocrine tumors (WDETs) of the appendix show characteristic morphologic features, including proliferation of cells with finely granulated eosinophilic cytoplasm. However, clear cell WDETs, which can present a diagnostic challenge, have been occasionally described, but it is unknown whether they represent a morphologic variant with distinct clinicopathologic features. Moreover, the clear cell appearance of the cytoplasm has never been explained. We studied 13 appendiceal WDETs composed of clear cells, which showed an immunophenotype identical to that of conventional appendiceal WDETs. Ultrastructural examination demonstrated abundant lipid accumulation. Patient survival was excellent and equal to that of conventional appendiceal WDETs. These neoplasms, which represent a lipid-rich variant of appendiceal WDETs, do not have different relevant clinical implications compared with conventional WDETs, but it is important to know of their existence for the differential diagnosis with more aggressive neoplasms, including goblet cell carcinoids and appendiceal metastases from clear cell carcinomas.
Mots-clé
Adolescent, Adult, Appendiceal Neoplasms/chemistry, Appendiceal Neoplasms/pathology, Biomarkers, Tumor/analysis, Carcinoid Tumor/chemistry, Carcinoid Tumor/pathology, Cell Proliferation, Child, Cytoplasm/chemistry, Cytoplasm/ultrastructure, Disease-Free Survival, Female, Humans, Immunoenzyme Techniques, Lipids/analysis, Male, Middle Aged, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/09/2016 13:54
Dernière modification de la notice
20/08/2019 14:14
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