Types of stereoselectivity in drug metabolism: a heuristic approach.

Details

Serval ID
serval:BIB_5C2555B88AA0
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Types of stereoselectivity in drug metabolism: a heuristic approach.
Journal
Drug Metabolism Reviews
Author(s)
Testa B.
ISSN
1097-9883 (Electronic)
ISSN-L
0360-2532
Publication state
Published
Issued date
2015
Volume
47
Number
2
Pages
239-251
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Stereochemical factors are known to play a significant role in the metabolism of drugs and other xenobiotics. Following Prelog's lead, types of metabolic stereoselectivity can be categorized as (i) substrate stereoselectivity (the differential metabolism of two or more stereoisomeric substrates) and (ii) product stereoselectivity (the differential formation of two or more stereoisomeric metabolites from a single substrate). Combinations of the two categories exist as (iii) substrate-product stereoselectivities, meaning that product stereoselectivity itself is substrate stereoselective. Here, published examples of metabolic stereoselectivities are examined in the light of these concepts. In parallel, a graphical scheme is presented with a view to facilitate learning and help researchers to solve classification problems.
Keywords
Animals, Biotransformation, Cytochrome P-450 Enzyme System, Humans, Inactivation, Metabolic, Models, Biological, Pharmaceutical Preparations/chemistry, Pharmaceutical Preparations/metabolism, Stereoisomerism, Substrate Specificity, Xenobiotics/chemistry, Xenobiotics/pharmacokinetics
Pubmed
Web of science
Create date
13/10/2015 18:16
Last modification date
20/08/2019 14:14
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