Balancing dormant and self-renewing hematopoietic stem cells.

Détails

ID Serval
serval:BIB_5C0FCEC9257B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Balancing dormant and self-renewing hematopoietic stem cells.
Périodique
Current opinion in genetics & development
Auteur(s)
Wilson A., Laurenti E., Trumpp A.
ISSN
1879-0380[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
19
Numéro
5
Pages
461-468
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
The mouse hematopoietic stem cell (HSC) is probably the best-understood somatic stem cell in higher organisms. Recent studies have shown that the highest self-renewal potential is most likely contained within an exceedingly small number of deeply dormant bone marrow HSCs. These stem cells are housed in individual niches that preserve their dormancy via signaling molecules such as Thrombopoietin, Angiopoietins, and Stem Cell Factor. In response to injury cues, dormant HSCs are efficiently activated and produce numerous progenitors and mature cells. A series of intracellular regulatory molecules including FoxOs, mTORC1, Fbw7, Egr1, Pbx1, pRb, c-Cbl, Myc, and Bmi1 mediate the processes of dormancy, cycling, self-renewal, differentiation, and survival, all of which control the behavior of HSCs.
Mots-clé
Animals, Cell Communication/physiology, Cell Cycle/physiology, Cell Proliferation, Cell Survival/physiology, Hematopoietic Stem Cells/physiology, Humans, Mice, Models, Biological, Signal Transduction/physiology, Stem Cell Niche/physiology, Wounds and Injuries/physiopathology
Pubmed
Création de la notice
15/01/2010 15:25
Dernière modification de la notice
20/08/2019 14:14
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