Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications.

Details

Serval ID
serval:BIB_5BF973130F92
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications.
Journal
European journal of pharmaceutics and biopharmaceutics
Author(s)
Berger J., Reist M., Mayer J.M., Felt O., Peppas N.A., Gurny R.
ISSN
0939-6411 (Print)
ISSN-L
0939-6411
Publication state
Published
Issued date
01/2004
Peer-reviewed
Oui
Volume
57
Number
1
Pages
19-34
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
This review presents a critical analysis of covalently and ionically crosslinked chitosan hydrogels and related networks for medical or pharmaceutical applications. The structural basis of these hydrogels is discussed with reference to the specific chemical interactions, which dictate gel formation. The synthesis and chemistry of these hydrogels is discussed using specific pharmaceutical examples. Covalent crosslinking leads to formation of hydrogels with a permanent network structure, since irreversible chemical links are formed. This type of linkage allows absorption of water and/or bioactive compounds without dissolution and permits drug release by diffusion. pH-controlled drug delivery is made possible by the addition of another polymer. Ionically crosslinked hydrogels are generally considered as biocompatible and well-tolerated. Their non-permanent network is formed by reversible links. Ionically crosslinked chitosan hydrogels exhibit a higher swelling sensitivity to pH changes compared to covalently crosslinked chitosan hydrogels. This extends their potential application, since dissolution can occur in extreme acidic or basic pH conditions.
Keywords
Biomedical Technology, Chitosan/chemical synthesis, Chitosan/chemistry, Chitosan/pharmacokinetics, Cross-Linking Reagents/chemistry, Hydrogels/chemical synthesis, Hydrogels/chemistry, Models, Molecular, Molecular Structure
Pubmed
Web of science
Create date
06/01/2019 13:37
Last modification date
13/05/2023 5:50
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