Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Haben selektive COX-2-Hemmer unerwünschte renale und kardiovaskuläre Wirkungen [Do selective COX-2 inhibitors have adverse renal and cardiovascular effects?].
Publication types: English Abstract ; Journal Article ; Review
Selective cyclooxygenase-2-inhibitors (COX-2) were developed as an alternative to the non-steroidal anti-inflammatory drugs (NSAID) in order to reduce their known gastrointestinal and renal toxicity. Several recent studies have shown the complex mechanism of the cyclooxygenase-2. The inhibition of the COX-2 has effects on renal hemodynamics, renal salt and water retention and may increase the thromboembolic and therefore the cardiovascular risk. The renal toxicity of the COX-2 inhibitors is similar to that of traditional NSAID. Regarding these data, COX-2 inhibitors should be prescribed with much caution to high risk patients, that is, patients with renal failure and/or cardiovascular diseases.
Anti-Inflammatory Agents, Non-Steroidal/administration & dosage, Anti-Inflammatory Agents, Non-Steroidal/toxicity, Cardiovascular Diseases/chemically induced, Cardiovascular Diseases/mortality, Cyclooxygenase 2 Inhibitors/administration & dosage, Cyclooxygenase 2 Inhibitors/toxicity, Dose-Response Relationship, Drug, Humans, Kidney Diseases/chemically induced, Kidney Diseases/mortality, Naproxen/administration & dosage, Naproxen/toxicity, Pyrazoles/administration & dosage, Pyrazoles/toxicity, Risk Assessment, Sulfonamides/administration & dosage, Sulfonamides/toxicity, Thromboembolism/chemically induced, Thromboembolism/mortality
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