Article: article from journal or magazin.
Expression of HLA-DR and common acute lymphoblastic leukemia antigens on glioma cells
European Journal of Immunology
Journal Article --- Old month value: Apr
The expression on several established human glioma cell lines of two well-defined differentiation antigens, HLA-DR and the common acute lymphoblastic leukemia antigen (CALLA) has been demonstrated. Rabbit anti-CALLA antiserum and monoclonal anti-Ia antibodies specifically lysed glioma cells in the presence of complement. Absorption of anti-CALLA antiserum and anti-Ia antibodies by glioma cells abolished their cytotoxicity against blasts isolated from a common acute lymphoblastic leukemia. Immunoprecipitation of solubilized glioma cells by monoclonal anti-Ia antibodies revealed two polypeptide chains of 28 and 33 kDa, whereas the anti-CALLA antiserum precipitated a single polypeptide chain of 100 kDa.
Absorption Animals Antibodies, Monoclonal/immunology Antibodies, Neoplasm/*immunology Antigens, Neoplasm/*immunology Autoradiography Glioma/*immunology Histocompatibility Antigens Class II/*immunology Humans Immune Sera/pharmacology Leukemia, Lymphoid/*immunology Rabbits
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