Expression of HLA-DR and common acute lymphoblastic leukemia antigens on glioma cells
Details
Serval ID
serval:BIB_5BBA0FDAB0A9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Expression of HLA-DR and common acute lymphoblastic leukemia antigens on glioma cells
Journal
European Journal of Immunology
ISSN
0014-2980
Publication state
Published
Issued date
04/1982
Peer-reviewed
Oui
Volume
12
Number
4
Pages
354-7
Notes
Journal Article --- Old month value: Apr
Abstract
The expression on several established human glioma cell lines of two well-defined differentiation antigens, HLA-DR and the common acute lymphoblastic leukemia antigen (CALLA) has been demonstrated. Rabbit anti-CALLA antiserum and monoclonal anti-Ia antibodies specifically lysed glioma cells in the presence of complement. Absorption of anti-CALLA antiserum and anti-Ia antibodies by glioma cells abolished their cytotoxicity against blasts isolated from a common acute lymphoblastic leukemia. Immunoprecipitation of solubilized glioma cells by monoclonal anti-Ia antibodies revealed two polypeptide chains of 28 and 33 kDa, whereas the anti-CALLA antiserum precipitated a single polypeptide chain of 100 kDa.
Keywords
Absorption
Animals
Antibodies, Monoclonal/immunology
Antibodies, Neoplasm/*immunology
Antigens, Neoplasm/*immunology
Autoradiography
Glioma/*immunology
Histocompatibility Antigens Class II/*immunology
Humans
Immune Sera/pharmacology
Leukemia, Lymphoid/*immunology
Rabbits
Pubmed
Web of science
Create date
20/01/2008 16:56
Last modification date
20/08/2019 15:14
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