Transforming growth factor-beta: the breaking open of a black box.

Détails

ID Serval
serval:BIB_5B8C3494D769
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Transforming growth factor-beta: the breaking open of a black box.
Périodique
Bioessays
Auteur(s)
Alevizopoulos A., Mermod N.
ISSN
0265-9247[print], 0265-9247[linking]
Statut éditorial
Publié
Date de publication
07/1997
Volume
19
Numéro
7
Pages
581-591
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Résumé
Transforming growth factor-beta (TGF-beta) and its related proteins regulate broad aspects of body development, including cell proliferation, differentiation, apoptosis and gene expression, in various organisms. Deregulated TGF-beta function has been causally implicated in the generation of human fibrotic disorders and in tumor progression. Nevertheless, the molecular mechanisms of TGF-beta action remained essentially unknown until recently. Here, we discuss recent progress in our understanding of the mechanism of TGF-beta signal transduction with respect to the regulation of gene expression, the control of cell phenotype and the potential usage of TGF-beta for the treatment of human diseases.
Mots-clé
Animals, Cell Communication/physiology, Cell Cycle/physiology, Cell Differentiation/physiology, Gene Expression Regulation/physiology, Humans, Immunologic Factors/therapeutic use, Multigene Family, Neoplasms/therapy, Organ Specificity, Receptors, Transforming Growth Factor beta/chemistry, Receptors, Transforming Growth Factor beta/classification, Signal Transduction/genetics, Signal Transduction/physiology, Transforming Growth Factor beta/chemistry, Transforming Growth Factor beta/genetics, Vertebrates/genetics, Vertebrates/physiology
Pubmed
Web of science
Création de la notice
24/01/2008 10:41
Dernière modification de la notice
20/08/2019 14:14
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