Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Transforming growth factor-beta: the breaking open of a black box.
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Transforming growth factor-beta (TGF-beta) and its related proteins regulate broad aspects of body development, including cell proliferation, differentiation, apoptosis and gene expression, in various organisms. Deregulated TGF-beta function has been causally implicated in the generation of human fibrotic disorders and in tumor progression. Nevertheless, the molecular mechanisms of TGF-beta action remained essentially unknown until recently. Here, we discuss recent progress in our understanding of the mechanism of TGF-beta signal transduction with respect to the regulation of gene expression, the control of cell phenotype and the potential usage of TGF-beta for the treatment of human diseases.
Animals, Cell Communication/physiology, Cell Cycle/physiology, Cell Differentiation/physiology, Gene Expression Regulation/physiology, Humans, Immunologic Factors/therapeutic use, Multigene Family, Neoplasms/therapy, Organ Specificity, Receptors, Transforming Growth Factor beta/chemistry, Receptors, Transforming Growth Factor beta/classification, Signal Transduction/genetics, Signal Transduction/physiology, Transforming Growth Factor beta/chemistry, Transforming Growth Factor beta/genetics, Vertebrates/genetics, Vertebrates/physiology
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