Lesionectomy of MRI detected lesions in children with epilepsy

Details

Serval ID
serval:BIB_5B44A6547F58
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lesionectomy of MRI detected lesions in children with epilepsy
Journal
Pediatric Neurosurgery
Author(s)
Montes  J. L., Rosenblatt  B., Farmer  J. P., O'Gorman  A. M., Andermann  F., Watters  G. V., Meagher-Villemure  K.
ISSN
1016-2291 (Print)
Publication state
Published
Issued date
1995
Volume
22
Number
4
Pages
167-173
Notes
PT - Case Reports PT - Journal Article
Abstract
The results of complete excision of cerebral lesions detected by MRI in 18 children presenting with epilepsy were analyzed. There were 14 boys and 4 girls with a mean age of 9.2 years. The average age of onset of seizures was 6.8 years. The mean time from onset of seizures to surgery was 2.3 years. Often, CT scans suggested that the lesions were indolent. MRI was better in differentiating neoplastic from developmental lesions. Angiography was non-contributory in this series. Interictal EEGs showed epileptiform activity correlating with imaging studies in 54% of children. The lesion was completely surgically excised in all patients. This was confirmed by intra-operative ultrasound and postoperative imaging. Electrocorticography was performed prior to and after the resection, but residual spiking did not lead to further resection. The average postoperative follow-up was 5.7 years. Five patients had low grade astrocytomas, 4 had gangliogliomas, 1 a mixed astrocytoma-oligodendroglioma, 3 had cortical dysplasia, 2 infantile desmoplastic gangliogliomas, 2 hamartomata, and 1 cavernous angioma. Sixteen patients have been seizure-free since surgery. Only 2 have partial seizures. Thus, all patients benefited from the resection, with respect to seizure control. In those with temporal lobe lesions, improvement in IQ was seen postoperatively. Early consideration of surgery in patients with epilepsy and lesions demonstrated by MRI is suggested
Keywords
Adolescent/Astrocytoma/diagnosis/physiopathology/surgery/Brain Mapping/Brain Neoplasms/Cerebral Cortex/Pathology/Child/Child,Preschool/Diagnosis,Differential/Electroencephalography/Epilepsy/Female/Follow-Up Studies/Ganglioglioma/Hamartoma/Hemangioma,Cavernous/Humans/Infant/Magnetic Resonance Imaging/Male/Oligodendroglioma
Pubmed
Web of science
Create date
29/01/2008 18:36
Last modification date
20/08/2019 14:14
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