Mapping a diversity of genetic interactions in yeast.

Détails

ID Serval
serval:BIB_5AE903AE7B6C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Mapping a diversity of genetic interactions in yeast.
Périodique
Current opinion in systems biology
Auteur(s)
van Leeuwen J., Boone C., Andrews B.J.
ISSN
2452-3100 (Print)
ISSN-L
2452-3100
Statut éditorial
Publié
Date de publication
12/2017
Peer-reviewed
Oui
Volume
6
Pages
14-21
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Genetic interactions occur when the combination of multiple mutations yields an unexpected phenotype, and they may confound our ability to fully understand the genetic mechanisms underlying complex diseases. Genetic interactions are challenging to study because there are millions of possible different variant combinations within a given genome. Consequently, they have primarily been systematically explored in unicellular model organisms, such as yeast, with a focus on pairwise genetic interactions between loss-of-function alleles. However, there are many different types of genetic interactions, such as those occurring between gain-of-function or heterozygous mutations. Here, we review recent advances made in the systematic analysis of such diverse genetic interactions in yeast, and briefly discuss how similar studies could be undertaken in human cells.
Mots-clé
complex haploinsufficiency, dosage interactions, epistasis, genetic interactions, higher-order interactions
Pubmed
Création de la notice
22/01/2019 17:06
Dernière modification de la notice
20/08/2019 15:13
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