Inproceedings: An article in a conference proceedings.
Bgee: integrating and comparing heterogeneous transcriptome data among species
Title of the conference
Data Integration in Life Sciences
Istrail S., Pevzner P., Waterman M.
Lecture Notes in Computer Science
5th International Workshop, DILS 2008, Evry, France, June 25-27, 2008. Proceedings
Gene expression patterns are a key feature in understanding gene function, notably in development. Comparing gene expression patterns between animals is a major step in the study of gene function as well as of animal evolution. It also provides a link between genes and phenotypes. Thus we have developed Bgee, a database designed to compare expression patterns between animals, by implementing ontologies describing anatomies and developmental stages of species, and then designing homology relationships between anatomies and comparison criteria between developmental stages. To define homology relationships between anatomical features we have developed the software Homolonto, which uses a modified ontology alignment approach to propose homology relationships between ontologies. Bgee then uses these aligned ontologies, onto which heterogeneous expression data types are mapped. These already include microarrays and ESTs.
gene expression pattern, homology, ontology, data integration
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