Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder.

Détails

ID Serval
serval:BIB_5A4DFFF8FC69
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder.
Périodique
Science translational medicine
Auteur(s)
Etkin A., Maron-Katz A., Wu W., Fonzo G.A., Huemer J., Vértes P.E., Patenaude B., Richiardi J., Goodkind M.S., Keller C.J., Ramos-Cejudo J., Zaiko Y.V., Peng K.K., Shpigel E., Longwell P., Toll R.T., Thompson A., Zack S., Gonzalez B., Edelstein R., Chen J., Akingbade I., Weiss E., Hart R., Mann S., Durkin K., Baete S.H., Boada F.E., Genfi A., Autea J., Newman J., Oathes D.J., Lindley S.E., Abu-Amara D., Arnow B.A., Crossley N., Hallmayer J., Fossati S., Rothbaum B.O., Marmar C.R., Bullmore E.T., O'Hara R.
ISSN
1946-6242 (Electronic)
ISSN-L
1946-6234
Statut éditorial
Publié
Date de publication
03/04/2019
Peer-reviewed
Oui
Volume
11
Numéro
486
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
A mechanistic understanding of the pathology of psychiatric disorders has been hampered by extensive heterogeneity in biology, symptoms, and behavior within diagnostic categories that are defined subjectively. We investigated whether leveraging individual differences in information-processing impairments in patients with post-traumatic stress disorder (PTSD) could reveal phenotypes within the disorder. We found that a subgroup of patients with PTSD from two independent cohorts displayed both aberrant functional connectivity within the ventral attention network (VAN) as revealed by functional magnetic resonance imaging (fMRI) neuroimaging and impaired verbal memory on a word list learning task. This combined phenotype was not associated with differences in symptoms or comorbidities, but nonetheless could be used to predict a poor response to psychotherapy, the best-validated treatment for PTSD. Using concurrent focal noninvasive transcranial magnetic stimulation and electroencephalography, we then identified alterations in neural signal flow in the VAN that were evoked by direct stimulation of that network. These alterations were associated with individual differences in functional fMRI connectivity within the VAN. Our findings define specific neurobiological mechanisms in a subgroup of patients with PTSD that could contribute to the poor response to psychotherapy.
Pubmed
Web of science
Création de la notice
22/04/2019 15:32
Dernière modification de la notice
20/08/2019 15:13
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