Hypothyroïdie infraclinique : faut-il encore traiter les personnes âgées ? Implications cliniques d’une nouvelle étude en médecine de famille [Subclinical hypothyroidism : should we still treat elderly patients? Clinical implications of a new trial in primary care]

Details

Serval ID
serval:BIB_5A30E111F1D9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Hypothyroïdie infraclinique : faut-il encore traiter les personnes âgées ? Implications cliniques d’une nouvelle étude en médecine de famille [Subclinical hypothyroidism : should we still treat elderly patients? Clinical implications of a new trial in primary care]
Journal
Revue medicale suisse
Author(s)
Collet T.H., Sykiotis G.P., Aubert C.E., Baumgartner C., Blum M.R., Feller M., Stettler C., Rodondi N.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
28/02/2018
Peer-reviewed
Oui
Volume
14
Number
596
Pages
470-474
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Subclinical hypothyroidism, defined as an elevated level of thyrotropin hormone (TSH) and normal thyroxin, is more frequent in women and above 65 years old. This condition is associated with an increased cardiovascular risk, in particular with TSH > 10,0 mIU/L. Although overt hypothyroidism is rare (prevalence of 0,3 %), levothyroxine has become the most prescribed medication in the US, while its indications are still debated. The European-funded TRUST trial showed no improvement in Hypothyroid Symptoms and Tiredness scores among patients ≥ 65 years with subclinical hypothyroidism treated with levothyroxine, and no improvement in blood pressure, weight, muscle strength and cognition. The results of this study call for a revision of the current international recommendations on the treatment of subclinical hypothyroidism.
Keywords
Aged, Clinical Trials as Topic, Female, Humans, Hypothyroidism/drug therapy, Prevalence, Primary Health Care, Thyrotropin/therapeutic use, Thyroxine/therapeutic use
Pubmed
Create date
03/03/2018 13:01
Last modification date
20/08/2019 14:13
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