T-cell activation positively correlates with cell-associated HIV-DNA level in viremic patients with primary or chronic HIV-1 infection.
Details
Serval ID
serval:BIB_59F3943B3CA5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
T-cell activation positively correlates with cell-associated HIV-DNA level in viremic patients with primary or chronic HIV-1 infection.
Journal
Aids (london, England)
Working group(s)
ANRS 116 SALTO Study Group
Contributor(s)
Bentata M., Girard P-., Meynard J-., Katlama C., Tubiana R., Simon A., Delfraissy J-., Gougard C., Sobel A., Levy Y., Pialoux G., Viard J-., Hoen B., Yeni P., Landmann R., Gastaut JA., Poizot-Martin I., Ragnaut JM., Morlat P., Bazin C., Lang JM., Massip P., Cassuto JP., Choutet P.
ISSN
1473-5571 (Electronic)
ISSN-L
0269-9370
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
28
Number
11
Pages
1683-1687
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
We investigated the relationship between the size of blood HIV reservoirs and T-cell activation in patients with primary HIV infection (PHI) and chronic HIV infection (CHI) before and after antiretroviral therapy (ART) interruption. Levels of T-cell activation strongly positively correlated with HIV-DNA levels in viremic PHI and CHI patients. In ART-treated CHI patients, residual immune activation was not associated with HIV-DNA levels. Interestingly, early levels of HIV-DNA in PHI predicted the extent of residual T-cell proliferation under ART.
Keywords
DNA, Viral/analysis, DNA, Viral/genetics, HIV Infections/immunology, HIV Infections/virology, HIV-1/isolation & purification, Humans, Lymphocyte Activation, Prospective Studies, T-Lymphocytes/immunology
Pubmed
Web of science
Create date
18/10/2016 16:52
Last modification date
20/08/2019 15:13
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