Distal tubular function in superficial rat tubules during volume expansion

Details

Serval ID
serval:BIB_59C06B2D0E79
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Distal tubular function in superficial rat tubules during volume expansion
Journal
American Journal of Physiology
Author(s)
Diezi  J., Nenniger  M., Giebisch  G.
ISSN
0002-9513
Publication state
Published
Issued date
09/1980
Volume
239
Number
3
Pages
F228-32
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Sep
Abstract
Free-flow micropuncture experiments were carried out on superficial late proximal and distal tubules during hydropenic conditions and during extracellular volume expansion. Fluid collected from tubules was analyzed for inulin and sodium. During volume expansion, renal perfusion pressure to one kidney was reduced so that the increase in distal sodium and fluid delivery that normally occurs after saline loading was prevented. Although urinary sodium excretion remained significantly elevated in such kidneys, the rate of sodium reabsorption along the distal tubules was not different from that occurring under nondiuretic conditions. It is concluded that those factors that reduce net sodium transport in the proximal tubule during extracellular volume expansion do not act on superficial distal tubules. Additional factors beyond the distal tubule contribute to increased sodium excretion and can be shown to be activated even when delivery of fluid and sodium out of superficial distal tubules is normal.
Keywords
Animals Biological Transport, Active Glomerular Filtration Rate Kidney/physiology Kidney Tubules/*metabolism Kidney Tubules, Distal/*metabolism Male Rats Sodium/*metabolism Water-Electrolyte Imbalance/*metabolism
Pubmed
Web of science
Create date
21/01/2008 11:54
Last modification date
20/08/2019 14:13
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