Effect of amiodarone on sinus node function in patients with sick sinus syndrome
Details
Serval ID
serval:BIB_59971CAA31BC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of amiodarone on sinus node function in patients with sick sinus syndrome
Journal
Clinical Cardiology
ISSN
0160-9289 (Print)
Publication state
Published
Issued date
08/1987
Volume
10
Number
8
Pages
451-2
Notes
Journal Article --- Old month value: Aug
Abstract
The effect of amiodarone on sinus node function has been studied in 9 patients with symptomatic sick sinus node as documented by Holter-ECG. All patients had programmable dual-chamber pacemakers. Sinus node activity was assessed by intermittently inhibiting the pacemakers before and after four weeks of oral amiodarone treatment. Sinus node function was not altered by amiodarone in 5 patients but was severely depressed in 4 patients. Thus, it is concluded that amiodarone cannot be used safely in all patients with the tachybrady syndrome for the treatment of symptomatic tachyarrhythmias without concomitant pacing.
Keywords
Aged
Amiodarone/therapeutic use/*toxicity
Electrocardiography
Female
Humans
Male
Middle Aged
Monitoring, Physiologic
Pacemaker, Artificial
Sick Sinus Syndrome/*drug therapy/therapy
Sinoatrial Node/*drug effects
Pubmed
Web of science
Open Access
Yes
Create date
15/02/2008 12:29
Last modification date
20/08/2019 15:13