Article: article from journal or magazin.
Cytokine mRNA profile of Epstein-Barr virus-stimulated highly differentiated T cells in multiple sclerosis: a pilot study.
Journal of Neuroimmunology
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
The reason why EBV-specific cellular immune responses are abnormal in multiple sclerosis (MS) patients is still missing. In this exploratory pilot study, we assessed IL-1beta, IL-2, IL-4, IL-6, IL-10, IL-17, IFN-gamma, TGF-beta1 and FOXP3 mRNA expression in EBV-stimulated highly differentiated T cells (T(HD)) of MS patients and healthy controls (HC). We found increased levels of IFN-gamma and IL-4 mRNA in CD8+ T(HD) cells of MS patients. All the other tested molecules were expressed similarly in MS patients and HC. Interestingly, increased IFN-gamma and IL-4 suggest that the control of EBV replication may be insufficient in MS patients.
Adult, Antigens, CD/metabolism, Cytokines/genetics, Cytokines/metabolism, Enzyme-Linked Immunosorbent Assay/methods, Epstein-Barr Virus Infections/immunology, Female, Flow Cytometry, Gene Expression Regulation, Viral/physiology, Herpesvirus 4, Human, Humans, Male, Middle Aged, Multiple Sclerosis/immunology, Multiple Sclerosis/pathology, Pilot Projects, RNA, Messenger/metabolism, Statistics, Nonparametric, T-Lymphocytes/immunology, T-Lymphocytes/virology
Web of science
Last modification date