Cytokine mRNA profile of Epstein-Barr virus-stimulated highly differentiated T cells in multiple sclerosis: a pilot study.
Details
Serval ID
serval:BIB_5972CAABD027
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cytokine mRNA profile of Epstein-Barr virus-stimulated highly differentiated T cells in multiple sclerosis: a pilot study.
Journal
Journal of Neuroimmunology
ISSN
1872-8421[electronic], 0165-5728[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
225
Number
1-2
Pages
167-170
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
The reason why EBV-specific cellular immune responses are abnormal in multiple sclerosis (MS) patients is still missing. In this exploratory pilot study, we assessed IL-1beta, IL-2, IL-4, IL-6, IL-10, IL-17, IFN-gamma, TGF-beta1 and FOXP3 mRNA expression in EBV-stimulated highly differentiated T cells (T(HD)) of MS patients and healthy controls (HC). We found increased levels of IFN-gamma and IL-4 mRNA in CD8+ T(HD) cells of MS patients. All the other tested molecules were expressed similarly in MS patients and HC. Interestingly, increased IFN-gamma and IL-4 suggest that the control of EBV replication may be insufficient in MS patients.
Keywords
Adult, Antigens, CD/metabolism, Cytokines/genetics, Cytokines/metabolism, Enzyme-Linked Immunosorbent Assay/methods, Epstein-Barr Virus Infections/immunology, Female, Flow Cytometry, Gene Expression Regulation, Viral/physiology, Herpesvirus 4, Human, Humans, Male, Middle Aged, Multiple Sclerosis/immunology, Multiple Sclerosis/pathology, Pilot Projects, RNA, Messenger/metabolism, Statistics, Nonparametric, T-Lymphocytes/immunology, T-Lymphocytes/virology
Pubmed
Web of science
Create date
07/10/2010 12:54
Last modification date
20/08/2019 14:12
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