Jonctions communicantes et pathologies. [Gap functions and diseases]

Détails

ID Serval
serval:BIB_595104D461EF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Jonctions communicantes et pathologies. [Gap functions and diseases]
Périodique
Revue Médicale Suisse
Auteur(s)
Allagnat  F., Krattinger  N., Nicod  P., Meda  P., Haefliger  J. A.
ISSN
1660-9379 (Print)
Statut éditorial
Publié
Date de publication
04/2005
Volume
1
Numéro
17
Pages
1126-30, 1132-3
Notes
English Abstract
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review --- Old month value: Apr 27
Résumé
Gap junctions are highly conserved structures that provide cells with a direct pathway for sharing ions, nutrients and other intracellular messengers, thus participating to the homeostasis of various tissues. Research on transgenic mice has revealed a major involvement of gap junctions proteins (connexins) in several cellular functions. At the same time, an increasing number of mutations of connexin genes has been linked to several hereditary diseases, including peripheral neuropathies, skin diseases, genetic deafness, cataracts and some forms of epilepsy. This review summarizes the state of knowledge about the implication of connexins in human pathologies.
Mots-clé
Connexins/*physiology Disease/*etiology Gap Junctions/*physiology Humans
Pubmed
Création de la notice
25/01/2008 14:48
Dernière modification de la notice
20/08/2019 15:12
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