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Chapter: chapter ou part
Creatine, central nervous system and creatine deficiency syndromes
Title of the book
Recent Researches in Modern Medicine
Address of publication
Braissant O., Wakamatsu H., Kuo-Kang I., Allegaert K., Lenbury Y., Wachholtz A.
2nd International Conference on Medical Physiology (PHYSIOLOGY '11), 2nd International Conference on Medical Pharmacology (PHARMACOLOGY '11), 2nd International Conference on Biochemistry and Medical Chemistry (BIOMEDCH '11), 2nd International Conference on Medical Histology andEmbryology (HISTEM '11), 2nd International Conference on Oncology (ONCOLOGY '11), 2nd International Conference on Psychiatry and Psychotherapy, (PSYCHO '11), Cambridge, United-Kingdom, February 23-25, 2011
It was long thought that most of brain creatine was of peripheral origin. However, recentworks have demonstrated that creatine crosses blood-brain barrier only with poor efficiency, and thatCNS must ensure parts of its creatine needs by its own creatine synthesis pathway, thank to the brainexpression of AGAT and GAMT (creatine synthesis) and SLC6A8 (creatine transporter). This newunderstanding of creatine metabolism and transport in CNS allows a better comprehension of creatinedeficiency syndromes, which are due to deficiencies in AGAT, GAMT and SLC6A8 and mainly affectthe brain of patients who show severe neurodevelopmental delay and present neurological symptomsin early infancy.
Creatine, brain, AGAT, GAMT, SLC6A8, guanidinoacetate, creatine deficiency
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