Human clusterin (CLI) maps to 8p21 in proximity to the lipoprotein lipase (LPL) gene
Details
Serval ID
serval:BIB_58E337792DF1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Human clusterin (CLI) maps to 8p21 in proximity to the lipoprotein lipase (LPL) gene
Journal
Genomics
ISSN
0888-7543 (Print)
Publication state
Published
Issued date
05/1993
Volume
16
Number
2
Pages
526-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Research Support, Non-U.S. Gov't --- Old month value: May
Abstract
Clusterin (gene symbol: CLI) is a post-translationally nicked, two-chain plasma and tissue glycoprotein of 80 kDa. It forms high-density lipoprotein complexes with apolipoprotein A-I in plasma, functions as an inhibitor of the cytolytic reaction of the terminal complement proteins C5 to C9, and is secreted by Sertoli cells in large amounts into the seminal fluid. By isolating and characterizing three partially overlapping cosmid clones, we have established the complete physical map of the clusterin gene which spans about 20 kb. The subchromosomal position of the clusterin gene (CLI) and the order of CLI and the lipoprotein lipase (LPL) gene were determined by fluorescence in situ hybridization. We show that CLI, previously assigned to chromosome 8, is located on 8p21 proximal to the LPL locus. Based on this localization we consider clusterin as a novel candidate gene determining susceptibility to atherosclerosis.
Keywords
Arteriosclerosis/genetics
Chromosome Mapping
*Chromosomes, Human, Pair 8
Clusterin
Cosmids
*Genes
Genetic Predisposition to Disease
Glycoproteins/*genetics
Humans
In Situ Hybridization, Fluorescence
Lipoprotein Lipase/genetics
*Molecular Chaperones
Molecular Sequence Data
Pubmed
Web of science
Create date
24/01/2008 16:19
Last modification date
20/08/2019 15:12