Short-term outcomes of surgical treatment for primary ileocaecal Crohn's disease: Results of the Crohn's(urg) study, a multicentre, retrospective, comparative analysis between inflammatory and complicated phenotypes.

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_589C52D3E97C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Short-term outcomes of surgical treatment for primary ileocaecal Crohn's disease: Results of the Crohn's(urg) study, a multicentre, retrospective, comparative analysis between inflammatory and complicated phenotypes.
Journal
Colorectal disease
Author(s)
Avellaneda N., Pellino G., Maroli A., Tottrup A., Bislenghi G., Colpaert J., D'Hoore A., Carvello M., Giorgi L., Juachon P., Harsløf S., de Buck Van Overstraeten A., Olivera P.A., Gomez J., Holubar S.D., Naranjo E.L., Steele S.R., Merchea A., Shaker A., Gallostra M.M., Kraft M., Kotze P.G., Maruyama B.Y., Wexner S.D., Garoufalia Z., Chen Z., Hahnloser D., Rrupa D., Buskens C., Haanappel A., Warusavitarne J., Williams K.J., Christensen P., Wolthuis A., Potolicchio A., Spinelli A.
ISSN
1463-1318 (Electronic)
ISSN-L
1462-8910
Publication state
Published
Issued date
07/2024
Peer-reviewed
Oui
Volume
26
Number
7
Pages
1415-1427
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Comparative Study
Publication Status: ppublish
Abstract
Recent evidence challenges the current standard of offering surgery to patients with ileocaecal Crohn's disease (CD) only when they present complications of the disease. The aim of this study was to compare short-term results of patients who underwent primary ileocaecal resection for either inflammatory (luminal disease, earlier in the disease course) or complicated phenotypes, hypothesizing that the latter would be associated with worse postoperative outcomes.
A retrospective, multicentre comparative analysis was performed including patients operated on for primary ileocaecal CD at 12 referral centres. Patients were divided into two groups according to indication of surgery for inflammatory (ICD) or complicated (CCD) phenotype. Short-term results were compared.
A total of 2013 patients were included, with 291 (14.5%) in the ICD group. No differences were found between the groups in time from diagnosis to surgery. CCD patients had higher rates of low body mass index, anaemia (40.9% vs. 27%, p < 0.001) and low albumin (11.3% vs. 2.6%, p < 0.001). CCD patients had longer operations, lower rates of laparoscopic approach (84.3% vs. 93.1%, p = 0.001) and higher conversion rates (9.3% vs. 1.9%, p < 0.001). CCD patients had a longer hospital stay and higher postoperative complication rates (26.1% vs. 21.3%, p = 0.083). Anastomotic leakage and reoperations were also more frequent in this group. More patients in the CCD group required an extended bowel resection (14.1% vs. 8.3%, p: 0.017). In multivariate analysis, CCD was associated with prolonged surgery (OR 3.44, p = 0.001) and the requirement for multiple intraoperative procedures (OR 8.39, p = 0.030).
Indication for surgery in patients who present with an inflammatory phenotype of CD was associated with better outcomes compared with patients operated on for complications of the disease. There was no difference between groups in time from diagnosis to surgery.
Keywords
Humans, Crohn Disease/surgery, Crohn Disease/complications, Female, Retrospective Studies, Male, Adult, Phenotype, Treatment Outcome, Postoperative Complications/etiology, Postoperative Complications/epidemiology, Middle Aged, Ileum/surgery, Young Adult, Cecum/surgery, Laparoscopy/methods, Laparoscopy/statistics & numerical data, Laparoscopy/adverse effects, Operative Time, Length of Stay/statistics & numerical data, Time Factors, Crohn, early, inflammatory, surgery, uncomplicated
Pubmed
Web of science
Open Access
Yes
Create date
14/06/2024 14:31
Last modification date
27/07/2024 6:11
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