Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria.

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Version: author
Serval ID
serval:BIB_589A6B4C7D09
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria.
Journal
Clinical Infectious Diseases
Author(s)
Segal B.H., Herbrecht R., Stevens D.A., Ostrosky-Zeichner L., Sobel J., Viscoli C., Walsh T.J., Maertens J., Patterson T.F., Perfect J.R., Dupont B., Wingard J.R., Calandra T., Kauffman C.A., Graybill J.R., Baden L.R., Pappas P.G., Bennett J.E., Kontoyiannis D.P., Cordonnier C., Viviani M.A., Bille J., Almyroudis N.G., Wheat L.J., Graninger W., Bow E.J., Holland S.M., Kullberg B.J., Dismukes W.E., De Pauw B.E.
ISSN
1537-6591
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
47
Number
5
Pages
674-683
Language
english
Abstract
Invasive fungal diseases (IFDs) have become major causes of morbidity and mortality among highly immunocompromised patients. Authoritative consensus criteria to diagnose IFD have been useful in establishing eligibility criteria for antifungal trials. There is an important need for generation of consensus definitions of outcomes of IFD that will form a standard for evaluating treatment success and failure in clinical trials. Therefore, an expert international panel consisting of the Mycoses Study Group and the European Organization for Research and Treatment of Cancer was convened to propose guidelines for assessing treatment responses in clinical trials of IFDs and for defining study outcomes. Major fungal diseases that are discussed include invasive disease due to Candida species, Aspergillus species and other molds, Cryptococcus neoformans, Histoplasma capsulatum, and Coccidioides immitis. We also discuss potential pitfalls in assessing outcome, such as conflicting clinical, radiological, and/or mycological data and gaps in knowledge.
Pubmed
Web of science
Open Access
Yes
Create date
19/03/2009 17:12
Last modification date
20/08/2019 14:12
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