Global analysis of dauer gene expression in Caenorhabditis elegans.

Détails

ID Serval
serval:BIB_58976ABCB9E1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Global analysis of dauer gene expression in Caenorhabditis elegans.
Périodique
Development
Auteur(s)
Wang J., Kim S.K.
ISSN
0950-1991 (Print)
ISSN-L
0950-1991
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
130
Numéro
8
Pages
1621-1634
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
The dauer is a developmental stage in C. elegans that exhibits increased longevity, stress resistance, nictation and altered metabolism compared with normal worms. We have used DNA microarrays to profile gene expression differences during the transition from the dauer state to the non-dauer state and after feeding of starved L1 animals, and have identified 1984 genes that show significant expression changes. This analysis includes genes that encode transcription factors and components of signaling pathways that could regulate the entry to and exit from the dauer state, and genes that encode components of metabolic pathways important for dauer survival and longevity. Homologs of C. elegans dauer-enriched genes may be involved in the disease process in parasitic nematodes.
Mots-clé
Animals, Behavior, Animal/physiology, Caenorhabditis elegans/genetics, Caenorhabditis elegans/growth & development, Energy Metabolism/genetics, Gene Expression Profiling, Gene Expression Regulation, Developmental, Larva/physiology, Oligonucleotide Array Sequence Analysis, Signal Transduction/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/11/2007 10:28
Dernière modification de la notice
20/08/2019 14:12
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