Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene

Détails

ID Serval
serval:BIB_584DD4C2F3A5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene
Périodique
Bipolar Disorders
Auteur(s)
Vincze Ilona, Perroud Nader, Buresi Catherine, Baud Patrick, Bellivier Frank, Etain Bruno, Fournier Claire, Karege Felicien, Matthey Marie-Louise, Preisig Martin, Leboyer Marion, Malafosse Alain
ISSN
1398-5647
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
10
Numéro
5
Pages
580-587
Langue
anglais
Notes
SAPHIRID:68925
Résumé
BACKGROUND: Recent data suggest that brain-derived neurotrophic factor (BDNF) and the serotonergic system are involved and interact in major depressive disorder and suicidal behavior (SB). Several family and population-based studies have reported associations between the BDNF gene and serotonin-related genes, specifically the serotonin transporter (5HTT) gene, with bipolar disorder (BD) and SB. However, despite the fact that gene-by-gene interaction between BDNF and 5HTT has been demonstrated in monoamine deficiencies in animals, this kind of interaction has never been tested in humans. Our hypothesis is that some BDNF and 5HTT polymorphisms might confer increased risk for BD and SB and that both genes may interact with each other. METHODS: To test this hypothesis, we genotyped the most common BDNF polymorphisms, G196A (Val66Met), A-633T and BDNF-LCPR, as well as 5HTT (5HTT-LPR), in 447 BD patients and 370 controls. RESULTS: We replicated the association previously reported between BDNF G196A (Val66Met) polymorphism and BD. We also observed a correlation between the number of G196 alleles and short alleles of 5HTT-LPR and the severity of SB in BD. However, we found no significant interaction between these two markers. CONCLUSIONS: These results suggest that BDNF G196A as well as 5HTT-LPR polymorphisms confer risk for SB in BD, but we did not observe any evidence for an interaction between them.
Pubmed
Web of science
Création de la notice
01/09/2008 16:19
Dernière modification de la notice
20/08/2019 15:12
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