RNA-mediated gene regulation is less evolvable than transcriptional regulation.

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License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_57E4C3B8E05C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
RNA-mediated gene regulation is less evolvable than transcriptional regulation.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Payne J.L., Khalid F., Wagner A.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Publication state
Published
Issued date
10/04/2018
Peer-reviewed
Oui
Volume
115
Number
15
Pages
E3481-E3490
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Much of gene regulation is carried out by proteins that bind DNA or RNA molecules at specific sequences. One class of such proteins is transcription factors, which bind short DNA sequences to regulate transcription. Another class is RNA binding proteins, which bind short RNA sequences to regulate RNA maturation, transport, and stability. Here, we study the robustness and evolvability of these regulatory mechanisms. To this end, we use experimental binding data from 172 human and fruit fly transcription factors and RNA binding proteins as well as human polymorphism data to study the evolution of binding sites in vivo. We find little difference between the robustness of regulatory protein-RNA interactions and transcription factor-DNA interactions to DNA mutations. In contrast, we find that RNA-mediated regulation is less evolvable than transcriptional regulation, because mutations are less likely to create interactions of an RNA molecule with a new RNA binding protein than they are to create interactions of a gene regulatory region with a new transcription factor. Our observations are consistent with the high level of conservation observed for interactions between RNA binding proteins and their target molecules as well as the evolutionary plasticity of regulatory regions bound by transcription factors. They may help explain why transcriptional regulation is implicated in many more evolutionary adaptations and innovations than RNA-mediated gene regulation.
Keywords
Animals, Binding Sites/genetics, DNA/metabolism, DNA-Binding Proteins/metabolism, Drosophila/genetics, Evolution, Molecular, Gene Expression Regulation/genetics, Gene Expression Regulation/physiology, Humans, Mutation, RNA/metabolism, RNA Processing, Post-Transcriptional/genetics, RNA-Binding Proteins/metabolism, Regulatory Sequences, Nucleic Acid, Transcription Factors/genetics, Transcription Factors/metabolism, Transcription, Genetic/genetics, RNA binding proteins, empirical genotype–phenotype map, evolution, gene regulation, transcription factors
Pubmed
Web of science
Open Access
Yes
Create date
04/09/2018 11:43
Last modification date
21/08/2019 6:09
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