Growth hormone response to thyrotropin-releasing hormone in children and adolescents: a reappraisal

Details

Serval ID
serval:BIB_57504121BCA4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Growth hormone response to thyrotropin-releasing hormone in children and adolescents: a reappraisal
Journal
Acta Endocrinologica. Supplementum
Author(s)
Theintz  G. E., Tang  J. Z., Marti  C., Bischof  P., Sizonenko  P. C.
ISSN
0300-9750 (Print)
Publication state
Published
Issued date
1986
Volume
279
Pages
51-9
Notes
Journal Article
Abstract
In normal subjects, thyrotropin-releasing hormone (TRH) is not involved in the control of growth hormone secretion. Paradoxical growth hormone (GH) responses to TRH have been described in acromegalic subjects and, recently, in some constitutionally tall children. To confirm this finding, we have examined the GH response to combined LHRH-TRH tests performed to assess the pituitary function of children with GH deficiency, tall stature before and during bromocriptine therapy, precocious or delayed puberty as well as in a group of patients of average height and normal bone age. Unlike prolactin, the GH "response" to TRH, in children followed longitudinally, is particularly heterogeneous with an unpredictable pattern of secretion in repeated tests. Over 90% of children display peaks of GH (greater than or equal to 5 ng/ml), of which 38% occur twice during the test period. Amplitude and frequency of GH peaks appear to be independent of height, chronological age or bromocriptine therapy. Secretory rate estimated by integrated surface area increases in parallel to sex steroids impregnation. The pattern of GH secretory episodes, the increase in mean GH secretion in parallel to the production of gonadal sex steroids and the failure of bromocriptine to affect GH secretion in constitutionally tall children allow to speculate that what is measured after TRH injection is normal spontaneous GH rhythm rather than a direct effect of TRH on GH secretion.
Keywords
Adolescent Body Height Bromocriptine/therapeutic use Child Female Gonadotropin-Releasing Hormone/diagnostic use Growth Hormone/deficiency/*secretion Humans Kinetics Male Pituitary Gland/physiopathology Prolactin/secretion Puberty, Delayed/physiopathology Puberty, Precocious/physiopathology Thyrotropin-Releasing Hormone/*diagnostic use/physiology
Pubmed
Create date
25/01/2008 10:31
Last modification date
20/08/2019 14:11
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