Successful Ovarian Stimulation for Fertility Preservation in a Patient with Chronic Myeloid Leukemia: Switch from Nilotinib to Interferon-α.

Détails

ID Serval
serval:BIB_56D9360E3614
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Successful Ovarian Stimulation for Fertility Preservation in a Patient with Chronic Myeloid Leukemia: Switch from Nilotinib to Interferon-α.
Périodique
The oncologist
Auteur(s)
Gazdaru S., Perey L., Rosselet A., Mathevet P., Chalandon Y., Vulliemoz N.
ISSN
1549-490X (Electronic)
ISSN-L
1083-7159
Statut éditorial
Publié
Date de publication
06/2018
Peer-reviewed
Oui
Volume
23
Numéro
6
Pages
719-721
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
The development of tyrosine-kinase inhibitors (TKIs) has improved survival of patients with chronic myeloid leukemia (CML). Some patients may become resistant to TKIs and require hematopoietic stem cell transplant (HSCT) that is highly gonadotoxic. Fertility preservation with ovarian stimulation might be indicated but is challenging if patients need to remain on TKIs until HSCT because TKIs may compromise follicular development and response to ovarian stimulation. We report the case of a patient with CML resistant to TKI and planned for an HSCT, in which treatment by TKI was replaced by interferon-α before and during ovarian stimulation for fertility preservation. Successful ovarian stimulation was performed, allowing cryopreservation of nine zygotes. Hematopoietic stem cell transplantation was performed, and at present, 3 years later, the patient presents a sustained major molecular response.
Mots-clé
Adult, Female, Fertility Preservation/methods, Humans, Interferon-alpha/pharmacology, Interferon-alpha/therapeutic use, Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy, Ovulation Induction/methods, Protein-Tyrosine Kinases/pharmacology, Protein-Tyrosine Kinases/therapeutic use, Pyrimidines/pharmacology, Pyrimidines/therapeutic use
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/12/2017 18:28
Dernière modification de la notice
28/09/2019 5:08
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