Pharmacogenomics of the OATP and OAT families.
Details
Serval ID
serval:BIB_56B4D87BEB7A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Pharmacogenomics of the OATP and OAT families.
Journal
Pharmacogenomics
ISSN
1462-2416 (Print)
ISSN-L
1462-2416
Publication state
Published
Issued date
04/2004
Peer-reviewed
Oui
Volume
5
Number
3
Pages
273-282
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Drug disposition is highly dependent on the interplay between drug metabolism and transport in organs such as the intestine, kidney, and liver. Genetically determined variation in drug transporter function or expression is now increasingly recognized to have a significant role as a determinant of intersubject variability in drug response. Similar to the discoveries of functional genetic variations in drug efflux transporters, such as multi-drug resistance proteins 1 and 2, there have been considerable advances in the identification of single nucleotide polymorphisms in transporters that facilitate cellular drug uptake. Among the uptake transporters, members of the organic anion-transporting polypeptides and organic anion transporters can mediate the cellular uptake of a large number of structurally divergent compounds. Accordingly, functionally relevant polymorphisms in these transporters may contribute to interindividual and interethnic variability in drug disposition and response. In this review, recent progress relating to pharmacogenomics of organic anion transporters will be outlined along with a compilation of currently known genetic polymorphisms.
Keywords
Animals, Genetic Variation, Humans, Organic Anion Transporters/genetics, Pharmaceutical Preparations/metabolism, Pharmacogenetics, Polymorphism, Genetic/genetics
Pubmed
Web of science
Create date
25/08/2023 5:17
Last modification date
05/08/2024 12:03