The use of Faecal Microbiota Transplantation (FMT) in Europe: A Europe-wide survey.

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serval:BIB_566EE2D61CC7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The use of Faecal Microbiota Transplantation (FMT) in Europe: A Europe-wide survey.
Journal
The Lancet regional health. Europe
Author(s)
Baunwall SMD, Terveer E.M., Dahlerup J.F., Erikstrup C., Arkkila P., Vehreschild M.J., Ianiro G., Gasbarrini A., Sokol H., Kump P.K., Satokari R., De Looze D., Vermeire S., Nakov R., Brezina J., Helms M., Kjeldsen J., Rode A.A., Kousgaard S.J., Alric L., Trang-Poisson C., Scanzi J., Link A., Stallmach A., Kupcinskas J., Johnsen P.H., Garborg K., Rodríguez E.S., Serrander L., Brummer R.J., Galpérine K.T., Goldenberg S.D., Mullish B.H., Williams H.R., Iqbal T.H., Ponsioen C., Kuijper E.J., Cammarota G., Keller J.J., Hvas C.L.
ISSN
2666-7762 (Electronic)
ISSN-L
2666-7762
Publication state
Published
Issued date
10/2021
Peer-reviewed
Oui
Volume
9
Pages
100181
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Faecal microbiota transplantation (FMT) is an emerging treatment modality, but its current clinical use and organisation are unknown. We aimed to describe the clinical use, conduct, and potential for FMT in Europe.
We invited all hospital-based FMT centres within the European Council member states to answer a web-based questionnaire covering their clinical activities, organisation, and regulation of FMT in 2019. Responders were identified from trials registered at clinicaltrials.gov and from the United European Gastroenterology (UEG) working group for stool banking and FMT.
In 2019, 31 FMT centres from 17 countries reported a total of 1,874 (median 25, quartile 10-64) FMT procedures; 1,077 (57%) with Clostridioides difficile infection (CDI) as indication, 791 (42%) with experimental indications, and 6 (0•3%) unaccounted for. Adjusted to population size, 0•257 per 100,000 population received FMT for CDI and 0•189 per 100,000 population for experimental indications. With estimated 12,400 (6,100-28,500) annual cases of multiple, recurrent CDI and indication for FMT in Europe, the current European FMT activity covers approximately 10% of the patients with indication. The participating centres demonstrated high safety standards and adherence to international consensus guidelines. Formal or informal regulation from health authorities was present at 21 (68%) centres.
FMT is a widespread routine treatment for multiple, recurrent CDI and an experimental treatment. Embedded within hospital settings, FMT centres operate with high standards across Europe to provide safe FMT. A significant gap in FMT coverage suggests the need to raise clinical awareness and increase the FMT activity in Europe by at least 10-fold to meet the true, indicated need.
NordForsk under the Nordic Council and Innovation Fund Denmark (j.no. 8056-00006B).
Keywords
Abbreviations: CDI, Clostridioides difficile infection, Clostridioides difficile, ECDC, European Centre for Disease Prevention and Control, FMT, FMT, Faecal microbiota transplantation, Faecal microbiota transplantation, IQR, Interquartile range, REDCap, Research Data Capture software, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, Stool banking, UEG, United Gastroenterology European
Pubmed
Web of science
Open Access
Yes
Create date
05/11/2021 19:28
Last modification date
25/01/2024 8:36
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