Population Variation and Genetic Control of Modular Chromatin Architecture in Humans.

Détails

ID Serval
serval:BIB_563E43FC3C7F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Population Variation and Genetic Control of Modular Chromatin Architecture in Humans.
Périodique
Cell
Auteur(s)
Waszak S.M., Delaneau O., Gschwind A.R., Kilpinen H., Raghav S.K., Witwicki R.M., Orioli A., Wiederkehr M., Panousis N.I., Yurovsky A., Romano-Palumbo L., Planchon A., Bielser D., Padioleau I., Udin G., Thurnheer S., Hacker D., Hernandez N., Reymond A., Deplancke B., Dermitzakis E.T.
ISSN
1097-4172 (Electronic)
ISSN-L
0092-8674
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
162
Numéro
5
Pages
1039-1050
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Chromatin state variation at gene regulatory elements is abundant across individuals, yet we understand little about the genetic basis of this variability. Here, we profiled several histone modifications, the transcription factor (TF) PU.1, RNA polymerase II, and gene expression in lymphoblastoid cell lines from 47 whole-genome sequenced individuals. We observed that distinct cis-regulatory elements exhibit coordinated chromatin variation across individuals in the form of variable chromatin modules (VCMs) at sub-Mb scale. VCMs were associated with thousands of genes and preferentially cluster within chromosomal contact domains. We mapped strong proximal and weak, yet more ubiquitous, distal-acting chromatin quantitative trait loci (cQTL) that frequently explain this variation. cQTLs were associated with molecular activity at clusters of cis-regulatory elements and mapped preferentially within TF-bound regions. We propose that local, sequence-independent chromatin variation emerges as a result of genetic perturbations in cooperative interactions between cis-regulatory elements that are located within the same genomic domain.
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/09/2015 14:26
Dernière modification de la notice
08/05/2019 18:50
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