Impact of CD14 Polymorphisms on Anti-Apolipoprotein A-1 IgG-Related Coronary Artery Disease Prediction in the General Population.

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Version: Author's accepted manuscript
Serval ID
serval:BIB_5572C0768CAA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of CD14 Polymorphisms on Anti-Apolipoprotein A-1 IgG-Related Coronary Artery Disease Prediction in the General Population.
Journal
Arteriosclerosis, thrombosis, and vascular biology
Author(s)
Antiochos P., Marques-Vidal P., Virzi J., Pagano S., Satta N., Hartley O., Montecucco F., Mach F., Kutalik Z., Waeber G., Vollenweider P., Vuilleumier N.
ISSN
1524-4636 (Electronic)
ISSN-L
1079-5642
Publication state
Published
Issued date
12/2017
Peer-reviewed
Oui
Volume
37
Number
12
Pages
2342-2349
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
We aimed to determine whether autoantibodies against apoA-1 (apolipoprotein A-1; anti-apoA-1 IgG) predict incident coronary artery disease (CAD), defined as adjudicated incident myocardial infarction, angina, percutaneous coronary revascularization, or bypass grafting, in the general population. We further investigated whether this association is modulated by a functional CD14 receptor single nucleotide polymorphism.
In a prospectively studied, population-based cohort of 5220 subjects (mean age 52.6±10.7 years, 47.4% males), followed over a median period of 5.6 years, subjects positive versus negative for anti-apoA-1 IgG presented a total CAD rate of 3.9% versus 2.8% (P=0.077) and a nonfatal CAD rate of 3.6% versus 2.3% (P=0.018), respectively. After multivariate adjustment for established cardiovascular risk factors, the hazard ratios of anti-apoA-1 IgG for total and nonfatal CAD were: hazard ratio=1.36 (95% confidence interval, 0.94-1.97; P=0.105) and hazard ratio=1.53 (95% confidence interval, 1.03-2.26; P=0.034), respectively. In subjects with available genetic data for the C260T rs2569190 single nucleotide polymorphism in the CD14 receptor gene (n=4247), we observed a significant interaction between anti-apoA-1 IgG and rs2569190 allele status with regards to CAD risk, with anti-apoA-1 IgG conferring the highest risk for total and nonfatal CAD in non-TT carriers, whereas being associated with the lowest risk for total and nonfatal CAD in TT homozygotes (P for interaction =0.011 and P for interaction =0.033, respectively).
Anti-apoA-1 IgG are independent predictors of nonfatal incident CAD in the general population. The strength of this association is dependent on a functional polymorphism of the CD14 receptor gene, a finding suggesting a gene-autoantibody interaction for the development of CAD.

Keywords
apolipoprotein A-1, autoantibodies, cholesterol, coronary artery disease, risk stratification, CD14 polymorphism, HDL cholesterol, autoimmunity
Pubmed
Web of science
Open Access
Yes
Create date
03/11/2017 16:36
Last modification date
20/08/2019 14:10
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