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Genetic loci influencing kidney function and chronic kidney disease.
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
Biological Transport, Creatinine/blood, Cystatin C/metabolism, Type="Geographic">Europe, Gene Expression Regulation, Genetic Markers/genetics, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotype, Glomerular Filtration Rate, Humans, Kidney/physiology, Kidney Failure, Chronic/genetics, Kidney Failure, Chronic/pathology, Models, Genetic, Colaus Study
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