Genetic loci influencing kidney function and chronic kidney disease.

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Version: author
Serval ID
serval:BIB_55509FC8B9C3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Genetic loci influencing kidney function and chronic kidney disease.
Journal
Nature Genetics
Author(s)
Chambers J.C., Zhang W., Lord G.M., van der Harst P., Lawlor D.A., Sehmi J.S., Gale D.P., Wass M.N., Ahmadi K.R., Bakker S.J., Beckmann J., Bilo H.J., Bochud Murielle, Brown M.J., Caulfield M.J., Connell J.M., Cook H.T., Cotlarciuc I., Davey Smith G., de Silva R., Deng G., Devuyst O., Dikkeschei L.D., Dimkovic N., Dockrell M., Dominiczak A., Ebrahim S., Eggermann T., Farrall M., Ferrucci L., Floege J., Forouhi N.G., Gansevoort R.T., Han X., Hedblad B., Homan van der Heide J.J., Hepkema B.G., Hernandez-Fuentes M., Hypponen E., Johnson T., de Jong P.E., Kleefstra N., Lagou V., Lapsley M., Li Y., Loos R.J., Luan J., Luttropp K., Maréchal C., Melander O., Munroe P.B., Nordfors L., Parsa A., Peltonen L., Penninx B.W., Perucha E., Pouta A., Prokopenko I., Roderick P.J., Ruokonen A., Samani N.J., Sanna S., Schalling M., Schlessinger D., Schlieper G., Seelen M.A., Shuldiner A.R., Sjögren M., Smit J.H., Snieder H., Soranzo N., Spector T.D., Stenvinkel P., Sternberg M.J., Swaminathan R., Tanaka T., Ubink-Veltmaat L.J., Uda M., Vollenweider P., Wallace C., Waterworth D., Zerres K., Waeber G., Wareham N.J., Maxwell P.H., McCarthy M.I., Jarvelin M.R., Mooser V., Abecasis G.R., Lightstone L., Scott J., Navis G., Elliott P., Kooner J.S.
ISSN
1546-1718 ([electronic])
1061-4036 ([linking])
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
42
Number
5
Pages
373-375
Language
english
Abstract
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
Keywords
Biological Transport, Creatinine/blood, Cystatin C/metabolism, Type="Geographic">Europe, Gene Expression Regulation, Genetic Markers/genetics, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotype, Glomerular Filtration Rate, Humans, Kidney/physiology, Kidney Failure, Chronic/genetics, Kidney Failure, Chronic/pathology, Models, Genetic, Colaus Study
OAI-PMH
oai:serval.unil.ch:BIB_55509FC8B9C3
DOI
10.1038/ng.566
Pubmed
20383145
Web of science
000277179500005
Create date
14/04/2010 15:07
Last modification date
20/08/2019 15:09
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