Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: A genome-wide association and polygenic scoring study.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_55074E2F2057
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: A genome-wide association and polygenic scoring study.
Périodique
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Auteur(s)
Mullins N., Perroud N., Uher R., Butler A.W., Cohen-Woods S., Rivera M., Malki K., Euesden J., Power R.A., Tansey K.E., Jones L., Jones I., Craddock N., Owen M.J., Korszun A., Gill M., Mors O., Preisig M., Maier W., Rietschel M., Rice J.P., Müller-Myhsok B., Binder E.B., Lucae S., Ising M., Craig I.W., Farmer A.E., McGuffin P., Breen G., Lewis C.M.
ISSN
1552-485X (Electronic)
ISSN-L
1552-4841
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
165
Numéro
5
Pages
428-437
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Epidemiological studies have recognized a genetic diathesis for suicidal behavior, which is independent of other psychiatric disorders. Genome-wide association studies (GWAS) on suicide attempt (SA) and ideation have failed to identify specific genetic variants. Here, we conduct further GWAS and for the first time, use polygenic score analysis in cohorts of patients with mood disorders, to test for common genetic variants for mood disorders and suicide phenotypes. Genome-wide studies for SA were conducted in the RADIANT and GSK-Munich recurrent depression samples and London Bipolar Affective Disorder Case-Control Study (BACCs) then meta-analysis was performed. A GWAS on suicidal ideation during antidepressant treatment had previously been conducted in the Genome Based Therapeutic Drugs for Depression (GENDEP) study. We derived polygenic scores from each sample and tested their ability to predict SA in the mood disorder cohorts or ideation status in the GENDEP study. Polygenic scores for major depressive disorder, bipolar disorder and schizophrenia from the Psychiatric Genomics Consortium were used to investigate pleiotropy between psychiatric disorders and suicide phenotypes. No significant evidence for association was detected at any SNP in GWAS or meta-analysis. Polygenic scores for major depressive disorder significantly predicted suicidal ideation in the GENDEP pharmacogenetics study and also predicted SA in a combined validation dataset. Polygenic scores for SA showed no predictive ability for suicidal ideation. Polygenic score analysis suggests pleiotropy between psychiatric disorders and suicidal ideation whereas the tendency to act on such thoughts may have a partially independent genetic diathesis. © 2014 Wiley Periodicals, Inc.
Pubmed
Web of science
Création de la notice
11/07/2014 11:23
Dernière modification de la notice
20/08/2019 15:09
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