Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
The biochemistry of drug metabolism--an introduction: part 5. Metabolism and bioactivity.
Chemistry and Biodiversity
Publication types: Journal Article ; Review
This review continues a general presentation of the metabolism of drugs and other xenobiotics begun in five recent issues of Chemistry & Biodiversity. The present Part is dedicated to the pharmacological and toxicological consequences of drug and xenobiotic metabolism. In other words, the key concepts here are activation vs. deactivation, toxification vs. detoxification, and their interplay. These concepts are illustrated with a number of medicinally, toxicologically, and environmentally relevant examples. But, far from being concerned only with individual cases, the review is based on broad classifications, global rationalizations, and synthetic hypotheses.
Drug Toxicity/metabolism, Pharmaceutical Preparations/chemistry, Pharmaceutical Preparations/metabolism, Prodrugs/chemistry, Prodrugs/metabolism, Xenobiotics/metabolism, Xenobiotics/toxicity
Web of science
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