A novel pediatric biventricular assist device: in vitro test results.

Details

Serval ID
serval:BIB_545F834E4935
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A novel pediatric biventricular assist device: in vitro test results.
Journal
Asaio Journal
Author(s)
Perrodin S.F., Tozzi P.
ISSN
1538-943X (Electronic)
ISSN-L
1058-2916
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
60
Number
3
Pages
329-334
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Most ventricular assist devices (VADs) currently used in infants are extracorporeal. These VADs require long-term anticoagulation therapy and extensive surgery, and two devices are needed for biventricular support. We designed a biventricular assist device based on shape memory alloy that reproduces the hemodynamic effects of cardiomyoplasty, supporting the heart with a compressing movement, and evaluated its performance in a dedicated mockup system. Nitinol fibers are the device's key component. Ejection fraction (EF), cardiac output (CO), and generated systolic pressure were measured on a test bench. Our test bench settings were a preload range of 0-15 mm Hg, an afterload range of 0-160 mm Hg, and a heart rate (HR) of 20, 30, 40, and 60 beats/min. A power supply of 15 volts and 3.5 amperes was necessary. The EF range went from 34.4% to 1.2% as the afterload and HR increased, along with a CO from 180 to 6 ml/min. The device generated a maximal systolic pressure of 25 mm Hg. Cardiac compression for biventricular assistance in child-sized heart using shape memory alloy is technically feasible. Further testing remains necessary to assess this VAD's in vivo performance range and its reliability.
Pubmed
Web of science
Create date
18/07/2014 19:06
Last modification date
20/08/2019 15:09
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