Preoperative combined 18-fluorodeoxyglucose positron emission tomography and computed tomography imaging in head and neck cancer: does it really improve initial N staging?

Détails

ID Serval
serval:BIB_54510AB6AD9D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Preoperative combined 18-fluorodeoxyglucose positron emission tomography and computed tomography imaging in head and neck cancer: does it really improve initial N staging?
Périodique
Acta Oto-laryngologica
Auteur(s)
Richard C., Prevot N., Timoshenko A.P., Dumollard J.M., Dubois F., Martin C., Prades J.M.
ISSN
1651-2251 (Electronic)
ISSN-L
0001-6489
Statut éditorial
Publié
Date de publication
2010
Volume
130
Numéro
12
Pages
1421-1424
Langue
anglais
Résumé
CONCLUSION: In our experience PET-CT cannot yet reliably predict the need for surgical neck dissection in patients with N0 neck. According to the results of PET-CT the neck dissection should be extended towards unusual lymph node areas.
OBJECTIVE: To analyze the value of PET-CT for the initial N staging, comparing PET-CT data with histopathological results of the modified radical neck dissection.
METHODS: Fifty patients with previously untreated head and neck squamous cell carcinoma were eligible for inclusion in this study. Modified radical unilateral or bilateral neck dissection was performed in all patients. PET-CT findings and histological findings were compared to determine their diagnostic sensitivity, specificity, accuracy, positive predictive value, and negative predictive value.
RESULTS: In all, 105 levels had pathologically diagnosed metastases: PET-CT was positive in 87 levels and negative in 18 levels. Also, 399 levels had negative postoperative histology findings: PET-CT was positive in 24 levels and negative in 375 levels. The false-positive over-staged and the false-negative under-staged rates were 27% and 12%, respectively.
Mots-clé
Aged, Aged, 80 and over, Carcinoma, Squamous Cell/pathology, Carcinoma, Squamous Cell/surgery, Female, Fluorodeoxyglucose F18, Humans, Hypopharyngeal Neoplasms/pathology, Hypopharyngeal Neoplasms/surgery, Laryngeal Neoplasms/pathology, Laryngeal Neoplasms/surgery, Lymph Nodes/pathology, Lymphatic Metastasis/pathology, Male, Middle Aged, Neck Dissection, Neoplasm Staging, Oropharyngeal Neoplasms/pathology, Oropharyngeal Neoplasms/surgery, Polymerase Chain Reaction, Sensitivity and Specificity, Tomography, X-Ray Computed
Pubmed
Web of science
Création de la notice
09/02/2016 13:49
Dernière modification de la notice
03/03/2018 17:17
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