Apelin in Normal Pregnancy and Pregnancies Complicated by Placental Insufficiency.

Détails

ID Serval
serval:BIB_5441B07913E0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Apelin in Normal Pregnancy and Pregnancies Complicated by Placental Insufficiency.
Périodique
Reproductive sciences
Auteur(s)
Van Mieghem T., Doherty A., Baczyk D., Drewlo S., Baud D., Carvalho J., Kingdom J.
ISSN
1933-7205 (Electronic)
ISSN-L
1933-7191
Statut éditorial
Publié
Date de publication
08/2016
Peer-reviewed
Oui
Volume
23
Numéro
8
Pages
1037-1043
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study
Publication Status: ppublish
Résumé
Apelin is a potent inotropic agent and causes endothelium-mediated vasodilation. Its cardiovascular profile suggests a role in the regulation of gestational hemodynamics.
We longitudinally assessed maternal serum apelin levels and hemodynamics (cardiac output and total peripheral resistance) between 20 and 34 weeks gestation in 18 women at high risk of placental dysfunction. Placental apelin staining was assessed by immunohistochemistry in placentas from uncomplicated pregnancies (n = 6), preterm deliveries (n = 6), preeclampsia (PET, n = 8), and isolated intrauterine growth restriction (IUGR, n = 8). Placental apelin gene expression was assessed by quantitative polymerase chain reaction.
In the high-risk cohort, 4 fetuses developed isolated IUGR and 6 women developed PET. We obtained a median of 5 (range 2-9) hemodynamic and apelin measurements per woman. Apelin levels throughout gestation were best fitted by a quadratic curve. Apelin levels between 20 and 26 weeks gestation correlated with total peripheral resistance (r = .57, P = .01) and showed a trend toward an inverse correlation with stroke volume (r = -.42, P = .08). Apelin serum levels were 30% lower in pregnancies complicated by IUGR than in uncomplicated pregnancies or in women with preeclampsia (P = .009). Placental apelin gene expression was similar in IUGR, PET, preterm, and term normal placentas. Apelin staining was seen both in syncytiotrophoblast and stroma of the placental villi. In IUGR placentas, apelin staining was strongly decreased in both compartments compared to normals. Preeclamptic placentas showed an intermediate staining.
Apelin levels mirror the cardiovascular changes seen in pregnancy. Serum and placental apelin levels are decreased in IUGR.

Mots-clé
Adult, Blood Pressure, Female, Fetal Growth Retardation/blood, Fetal Growth Retardation/epidemiology, Fetal Growth Retardation/metabolism, Gestational Age, Humans, Intercellular Signaling Peptides and Proteins/blood, Intercellular Signaling Peptides and Proteins/metabolism, Longitudinal Studies, Placenta/metabolism, Placental Insufficiency/blood, Placental Insufficiency/epidemiology, Placental Insufficiency/metabolism, Pre-Eclampsia/blood, Pre-Eclampsia/epidemiology, Pre-Eclampsia/metabolism, Pregnancy, apelin, endocrine, fetal, growth, growth restriction, physiology, preeclampsia
Pubmed
Web of science
Création de la notice
20/02/2016 16:41
Dernière modification de la notice
20/08/2019 14:09
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